罗沙替丁治疗消化性溃疡或急性胃黏膜病变引起的上消化道出血效果观察  被引量:2

Effect of roxatidine on upper gastrointestinal bleeding caused by peptic ulcer or acute gastric mucosal lesion

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作  者:吴忠辉 WU Zhonghui(Pengpai Memorial Hospital of Haifeng,Guangdong Province,Haifeng 516400,China)

机构地区:[1]广东省海丰县彭湃纪念医院

出  处:《临床合理用药杂志》2019年第19期11-12,共2页Chinese Journal of Clinical Rational Drug Use

摘  要:目的观察罗沙替丁治疗消化性溃疡或急性胃黏膜病变引起的上消化道出血的效果.方法选取2016年4月-2018年5月于医院接受治疗的消化性溃疡或急性胃黏膜病变引起的上消化道出血患者60例,采用随机数表法分为观察组和对照组各30例.观察组给予罗沙替丁治疗,对照组给予兰索拉唑治疗,比较2组临床疗效、出血停止时间、大便隐血转阴时间、住院时间及不良反应.结果观察组总有效率为96.67%高于对照组的90.00%,差异有统计学意义(χ^2=4.043,P<0.05).观察组出血停止时间、大便隐血转阴时间及住院时间均短于对照组,差异均有统计学意义(P<0.05).2组不良反应发生率比较差异无统计学意义(χ^2=0.218,P>0.05).结论罗沙替丁治疗消化性溃疡或急性胃黏膜病变引起的上消化道出血效果较好,安全性高,值得在临床上进一步推广和应用.Objective To observe the effect of rosartidine on upper gastrointestinal bleeding caused by peptic ulcer or acute gastric mucosal lesions. Methods 60 cases of upper gastrointestinal bleeding caused by peptic ulcer or acute gastric mucosal lesion from April 2016 to May 2018 were selected,and they were randomly divided into observation group( 30 cases) and control group ( 30 cases). The observation group was treated with rosatidine,and the control group was treated with lansoprazole,the clinical efficacy,bleeding stop time,fecal occult blood loss time,hospitalization time and adverse reactions were compared between the two groups. Results The total effective rate of the observation group( 96. 67%) was higher than that of the control group( 90. 00%),and the difference was statistically significant(χ2 = 4. 043,P < 0. 05). The bleeding stop time, fecal occult blood loss time and hospitalization time in the observation group were shorter than the control group,and the differ- ences were statistically significant( P < 0. 05). There was no significant difference in the incidence of adverse reactions between the two groups(χ2 = 0. 218,P > 0. 05). Conclusion Rosaltine is effective in treating upper digestive tract bleeding caused by peptic ulcer or acute gastric mucosal lesions,and it is safe and worthy of further promotion and application in clinical practice.

关 键 词:罗沙替丁 消化性溃疡 急性胃黏膜病变 上消化道出血 治疗效果 

分 类 号:R573[医药卫生—消化系统]

 

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