三阴性乳腺癌干细胞研究进展  

Research progress of cancer stem cells in triple-negative breast cancer

作　　者：亢野 李建一[2] 杨向红[1] Kang Ye;Li Jianyi;Yang Xianghong(Department of Pathology,Shengjing Hospital of China Medical University,Shenyang 110000,China;FirstDepartment of Breast Surgery,Shengjing Hospital of China Medical University,Shenyang 110000,China)

机构地区：[1]中国医科大学附属盛京医院病理科,沈阳110000 [2]中国医科大学附属盛京医院第一乳腺外科,沈阳110000

出　　处：《国际肿瘤学杂志》2019年第6期362-365,共4页Journal of International Oncology

基　　金：国家自然科学基金(81528010).

摘　　要：三阴性乳腺癌(TNBC)富含肿瘤干细胞(CSC),并具有独特的维持其CSC表型的分子机制和肿瘤微环境.CSC可促进TNBC的化疗耐药与复发.阻断关键分子或改变肿瘤微环境能够削减CSC,进而抑制TNBC的肿瘤生长,并逆转化疗耐药.There are abundant cancer stem cells (CSCs) in triple-negative breast cancer TNBC).CSCs can maintain their phenotype by unique molecular mechanism and tumor microenvironment,and can promote the chemotherapy resistance and recurrence of TNBC.Blocking these key molecules or altering tumor microenvironment can reduce CSCs,and then inhibited cancer growth and reverse chemotherapy resistance of TNBC.

关 键 词：乳腺肿瘤 肿瘤干细胞 治疗 抗药性 三阴性乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]