小胶质细胞在多发性硬化中的作用和机制  

The role and mechanism of microglia cells in multiple sclerosis

作　　者：朱雨薇 孙博[1] Zhu Yuwei;Sun Bo(Department of Neurobiology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学神经生物教研室,150081

出　　处：《国际免疫学杂志》2019年第4期407-411,共5页International Journal of Immunology

基　　金：国家自然基金重点项目(81371323);黑龙江省卫生厅项目(2009-219);黑龙江省卫生厅项目(2009-218).

摘　　要：由于啮齿类、灵长类和人的中枢神经系统中存在淋巴引流系统的发现,小胶质细胞在多发性硬化中的作用重新受到关注。利用实验动物模型研究发现小胶质细胞除了吞噬作用,还能够活化后提呈抗原,并且分泌多种促炎性和抑炎性的细胞因子和趋化因子,调节其他免疫细胞的应答,影响疾病进程。然而目前国内外针对小胶质细胞的临床治疗方案还有很多问题和局限性。因此有必要从小胶质细胞参与多发性硬化的机制和针对小胶质细胞的临床治疗手段等方面阐述其在多发性硬化疾病中的具体作用。Since lymphatic draining vessels in the central nervous system of human,primates and rodents,have been identified,the role of microglia in multiple sclerosis is a focus again.Exploiting the experimental animal model,it is discovered that microglia can not only perform phagocytosis but also be activated to present antigens and secrete various pro-and anti-inflammatory cytokines and chemokines so as to regulate the response of other immune cells and affect the disease progress.However,many problems and limitations are to be resolved in current microglia-targeted therapies home and abroad.Therefore,it is necessary to clarify the role of microglia in multiple sclerosis from the point of the mechanism and means of treatment.

关 键 词：小胶质细胞 多发性硬化 抗原呈递 吞噬作用 药物作用 

分 类 号：R744.51[医药卫生—神经病学与精神病学]