血小板膜糖蛋白与缺血性脑血管病的相关性研究  

Study on the Correlation between Platelet Membrane Glycoprotein and Ischemic Cerebrovascular Disease

作　　者：刘圣勋 彭新国[1] 袁笑[1] 王健[1] 王娟[1] 李金玲[1] 李娜[1] LIU Sheng-xun;PENG Xin-guo;YUAN Xiao;WANG Jian;WANG Juan;LI Jin-ling;LI Na(Binzhou Medical University Hospital, Binzhou, Shandong 256600)

机构地区：[1]滨州医学院附属医院

出　　处：《智慧健康》2019年第19期109-110,共2页Smart Healthcare

基　　金：山东省医药卫生科技发展计划。项目名称:血小板膜糖蛋白与缺血性脑血管病关系的研究,项目编号:2017WS369

摘　　要：目的研究血小板膜糖蛋白与缺血性脑血管病的相关性.方法选取我院神经外科在2016年8月至2018年8月收治的100例缺血性脑血管病患者为研究对象,将其作为观察组.另选取同期收治的100例健康体检者作为对照组,分别检测两组研究对象的血小板膜糖蛋白GPIb/Ⅸ/Ⅴ复合物以及血小板聚集率水平.结果观察组患者的血小板膜糖蛋白GPIb/Ⅸ/Ⅴ复合物以及血小板聚集率水平均高于对照组(P<0.05),且观察组患者的血小板膜糖蛋白GPIb/Ⅸ/Ⅴ复合物以及血小板聚集率水平成正比.结论血小板膜糖蛋白的表达水平升高后,能够使血小板聚集能力和活化程度增强,而导致缺血性脑血管病发生发展的主要原因在于GPIb/Ⅸ/Ⅴ复合物表达以及血小板聚集.Objective To study the correlation between platelet membrane glycoprotein and ischemic cerebrovascular disease. Methods One hundred patients with ischemic cerebrovascular disease admitted to neurosurgery department of our hospital from August 2016 to August 2018 were selected as the research object, and they were taken as the observation group. Another 100 healthy subjects who were admitted to the same period were selected as the control group, and the platelet membrane glycoprotein GPIb/Ⅸ/Ⅴ complex and platelet aggregation rate were measured in the two groups. Results The platelet membrane glycoprotein GPIb/Ⅸ/Ⅴ complex and platelet aggregation rate were higher in the observation group than in the control group (P<0.05), and the platelet membrane glycoprotein GPIb/Ⅸ/Ⅴ complex in the observation group and The level of platelet aggregation is directly proportional. Conclusion The increased expression level of platelet membrane glycoprotein can increase the ability of platelet aggregation and activation, and the main cause of the development of ischemic cerebrovascular disease is GPIb/Ⅸ/Ⅴ complex expression and platelet aggregation.

关 键 词：血小板膜糖蛋白 缺血性脑血管病 血小板聚集 

分 类 号：R743[医药卫生—神经病学与精神病学]