健脾补肾方联合化疗在大肠癌术后复发转移中的应用效果及对生存质量的影响研究  

Effect of Jianpi Bushen Recipe Combined with Chemotherapy on Recurrence and Metastasis of Colorectal Cancer and Its Effect on Quality of Life

作　　者：张计训[1] 司仙科[1] 李炜[1] 杨佳华[1] 曹亦军[1] ZHANG Jixun;SI Xianke;LI Wei;YANG Jiahua;CAO Yijun(General Microsurgery,Putuo Hospital Affiliated to Shanghai University of TCM,Shanghai 200062,China)

机构地区：[1]上海中医药大学附属普陀医院普外微创外科

出　　处：《中华中医药学刊》2019年第7期1585-1587,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(81503434)

摘　　要：目的:探讨在大肠癌术后复发转移中,化疗、健脾补肾方联合应用的临床价值。方法:大肠癌术后复发转移患者(共80例)依照入院单双号随机分成两组(例数一致),其中,参照组接受化疗,治疗组与此同时另接受健脾补肾方治疗,对两组患者的治疗成效予以评价。结果:治疗组的疾病控制率(DCR)、总有效率(ORR)均显著高于参照组,差异具有统计学意义(P<0.05);两组治疗前的糖类抗原199(CA199)、癌胚抗原(CEA)对比,差异无统计学意义(P>0.05);治疗组治疗后的CA199、CEA均显著低于参照组,且差异有统计学意义(P<0.05);治疗组的生存质量显著优于参照组,差异具有统计学意义(P<0.05);治疗组的总不良反应发生率显著低于参照组(15.00%vs 47.50%),差异具有统计学意义(P<0.05)。结论:在大肠癌术后复发转移中,健脾补肾方联合化疗的应用效果突出,有助于患者不良反应的控制和生存质量的改善。Objective:To explore the clinical value of combined application of chemotherapy andJianpi Bushen Recipe in recurrence and metastasis of colorectal cancer.Methods:Patients with recurrence and metastasis of colorectal cancer diagnosed(80 cases in total) were randomly divided into two groups according to the admission number(the number of cases was consistent). Among them, the reference group received chemotherapyand the treatment group received Jianpi Bushen Recipe at the same time. We evaluated the treatment effectiveness of two groups.Results:The disease control rate(DCR) and total effective rate(ORR) of the treatment group were significantly higher than those of the reference group.The difference was statistically significant(P<0.05).The two groups’ pre-treatment carbohydrate antigen 199(CA199) and carcinoembryonic antigen(CEA) were not statistically significant(P>0.05). The CA199 and CEA in the treatment group were significantly lower than those of the reference group, and the difference was statistically significant(P<0.05). The quality of life of the treatment group was excellent. In the reference group, the difference was statistically significant(P<0.05).The incidence of total adverse reactions in the treatment group was significantly lower than that in the reference group(15.00% vs 47.50%)and the difference was statistically significant(P<0.05).Conclusion:In the postoperative recurrence and metastasis of colorectal cancer, the application of Jianpi Bushen Recipe combined with chemotherapy is outstanding, which is helpful for the control of adverse reactions and the improvement of quality of life.

关 键 词：健脾补肾方 化疗 大肠癌术后复发转移 应用效果 生存质量 影响研究 

分 类 号：R735.3[医药卫生—肿瘤]