祛邪消积汤联合放化疗治疗胃癌根治术后腹腔淋巴结转移癌临床观察及对免疫指标的影响  

Clinical Observation of Quxie Xiaoji Decoction Combined with Radiotherapy and Chemotherapy in Treatment of Abdominal Lymph Node Metastasis after Radical Gastrectomy for Gastric Cancer and Its Influence on Immune Index

作　　者：孙兆[1] 严玉月 SUN Zhao;YAN Yuyue(Department of Integrated Traditional Chinese and Western Medicine,The Affiliated Hospital of Qinghai University,Xining 810001,Qinghai,China;Department of Dermatology,The Fifth People's Hospital of Qinghai Province,Xining 810007,Qinghai,China)

机构地区：[1]青海大学附属医院中西医结合科,青海西宁810001 [2]青海省第五人民医院皮肤科,青海西宁810007

出　　处：《中华中医药学刊》2019年第7期1737-1740,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：青海省中藏医局研究项目(2015103)

摘　　要：目的:观察祛邪消积汤联合放化疗治疗胃癌根治术后腹腔淋巴结转移癌患者的临床效果及对免疫功能的影响。方法:选取胃癌根治术后腹腔淋巴转移癌患者70例,随机分为对照组及观察组,对照组采用放化疗,观察组在放化疗的基础上联合使用祛邪消积汤治疗,连续治疗6周。观察比较治疗前后两组患者外周血T淋巴细胞及NK细胞的比例,血清肿瘤标志物(VEGF、CEA和CA19-9)的水平;绘制生存曲线,比较两组患者PFS及OS;采用KPS评分评价两组患者的生存质量;比较治疗后两组的临床疗效及不良反应。结果:治疗后两组患者外周血T淋巴细胞及NK均明显高于治疗前,并且观察组患者各项指标显著高于对照组(P<0.05)。观察组治疗6周后、最后1次复诊时血清中VEGF、CA19-9、CEA水平均显著低于治疗前,并且明显较对照组低(P<0.05)。对照组患者的中位PFS为14个月,中位OS为29个月,观察组患者的中位PFS为20个月,中位OS为40个月,两组比较差异显著(P<0.05)。观察组的临床疗效高于对照组(P<0.05),观察组的生存质量也明显优于对照组(P<0.05),不良反应明显少于对照组(P>0.05)。结论:祛邪消积汤联合放化疗治疗胃癌根治术后腹腔淋巴转移癌具有良好的临床疗效,提高机体免疫功能,延长患者生存期,提高生存质量,值得在临床上推广。Objective: To observe the clinical effect of Quxie Xiaoji Decoction combined with radiotherapy and chemotherapy on patients with abdominal lymph node metastasis after radical gastrectomy. Methods: Seventy patients with lymph node metastasis after radical gastrectomy were randomly divided into control group and observation group. The control group received radiotherapy and chemotherapy. The observation group was treated with Quxie Xiaoji Decoction on the basis of radiotherapy and chemotherapy. Continuous treatment lasted for 6 weeks. The ratios of peripheral blood T lymphocytes and NK cells, serum tumor markers(VEGF, CEA and CA19-9) were compared between the two groups before and after treatment. The survival curves were compared and the PFS and OS were compared between the two groups. The KPS score was used to evaluate the scores. The quality of life of the two groups’ patients,the clinical efficacy and adverse reactions of the two groups after treatment were compared. Results: T lymphocytes and NK in peripheral blood of the two groups were significantly higher than those before treatment, and the indexes of the observation group were significantly higher than those of the control group(P<0.05). The serum levels of VEGF, CA19-9 and CEA in the observation group were significantly lower than those before treatment after 6 weeks treatment and at the last time, and were significantly lower than those of the control group(P<0.05). The median PFS was 14 months in the control group and the median OS was 29 months. The median PFS was 20 months and the median OS was 40 months in the observation group. The difference between the two groups was significant(P<0.05).. The clinical efficacy of the observation group was higher than that of the control group(P<0.05). The quality of life of the observation group was also significantly better than that of the control group(P<0.05), and the adverse reactions were significantly less than those of the control group(P>0.05). Conclusion: Quxie Xiaoji Decoction combined with radiother

关 键 词：祛邪消积 胃癌根治术 腹腔淋巴转移癌 T淋巴细胞 

分 类 号：R735.2[医药卫生—肿瘤]