中药口服加保留灌肠疗法配合FOLFOX方案对低位直肠癌保肛术的疗效及安全性分析  

Efficacy and Safety of Oral Chinese Medicine and Retention Enema Combined with FOLFOX Regimen in Patients with Low Rectal Cancer Undergoing Anal Preservation Surgery

作　　者：蔡剑辉[1] 厉金雷[1] 任约翰[1] 龚雪迎 CAI Jianhui;LI Jinlei;REN Yuehan;GONG Xueying(The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang,China;Zhejiang Province People's Hospital,Hangzhou 310014,Zhejiang,China)

机构地区：[1]温州医科大学附属第一医院,浙江温州325000 [2]浙江省人民医院,浙江杭州310014

出　　处：《中华中医药学刊》2019年第7期1751-1754,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省自然科学基金项目(LY17H16099)

摘　　要：目的:分析中药口服加保留灌肠疗法配合FOLFOX方案对低位直肠癌保肛术患者的疗效及安全性。方法:选取在医院(2016年1月-2018年1月)行低位直肠癌保肛术患者80例,随机分为两组。对照组患者采用FOLFOX方案进行治疗,观察组患者在中药口服加保留灌肠疗法配合FOLFOX方案治疗,分析两组患者治疗后的临床效果。结果:观察组患者肠鸣音恢复时间、首次排气时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者SAA、SOD、VEGF水平、肛门直肠测压各指标比较,差异无统计学意义(P>0.05)。治疗后,观察组患者SOD水平及ARP、MSP、 RAIA、MTV水平高于对照组,SAA、VEGF水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者SF-36评分、肛门功能评分比较,差异无统计学意义(P>0.05)。治疗后,观察组患者SF-36评分、肛门功能评分高于对照组,差异有统计学意义(P<0.05)。结论:中药口服加保留灌肠疗法配合FOLFOX方案可促进低位直肠癌保肛术后胃肠功能的恢复,降低SAA、VEGF水平,对肛门功能和生活质量影响较小。Objective:To analyze the efficacy and safety of oral retention enema combined with FOLFOX in patients with low rectal cancer undergoing anal sphincter preservation. Methods:A total of 80 patients with low rectal cancer undergoing anus preservation from January 2016 to January 2018 were randomly divided into two groups. The patients in the control group were treated with FOLFOX regimen, and the patients in the observation group were treated with oral Chinese medicine and retention enema combined with FOLFOX regimen. The clinical effects of the two groups were analyzed. Results:The recovery time and the first exhaust time of the patients in the observation group were shorter than those in the control group(P<0.05). Before treatment, there was no significant difference in VEGF level or anorectal manometry between the two groups(P>0.05). After treatment, the levels of SOD, ARPU MSP and RAIA MTV in the observation group were higher than those in the control group(P<0.05), and the levels of VEGF in the control group were lower than those in the control group(P<0.05). Before treatment, there was no significant difference in SF-36 score or anal function score between the two groups(P>0.05). After treatment, the scores of SF-36 and anal function in the observation group were significantly higher than those in the control group(P<0.05). Conclusion:Oral administration of traditional Chinese medicine and retention enema combined with FOLFOX can promote the recovery of gastrointestinal function after anus preserving operation in low rectal cancer, reduce SAA and VEGF, and has less influence on the function of the anus and the quality of life.

关 键 词：保留灌肠 FOLFOX方案 低位直肠癌保肛术 肛门功能 生活质量 

分 类 号：R735.37[医药卫生—肿瘤]