氨磺必利对阴性症状精神分裂症患者有效率、生活质量和不良反应的影响  

Effect of amsulfuropride on efficacy, quality of life and adverse reactions in patients with negative symptoms of schizophrenia

作　　者：郑鸿伟[1] 王灵君[1] 张亚莉[1] 刘惠敏[2] 刘光伟[1] 邓巧恩 杨二梅[1] 赵栋 ZHENG Hongwei;WANG Lingjun;ZHANG Yali;LIU Huimin;LIU Guangwei;DENG Qiaoen;YANG Ermei;ZHAO Dong(Shijiazhuang Eighth Hospital of Hebei Province,Shijiazhuang 050081,China;PLA Bethune International Peace Hospital,Shijiazhuang 050082,China)

机构地区：[1]河北省石家庄市第八医院,石家庄050081 [2]解放军白求恩国际和平医院,石家庄050082

出　　处：《新疆医科大学学报》2019年第9期1171-1173,1179,共4页Journal of Xinjiang Medical University

基　　金：石家庄市科学技术研究与发展指导计划(161461043)

摘　　要：目的探讨氨磺必利对阴性症状精神分裂症患者有效率、生活质量和不良反应的影响。方法选取河北省石家庄市第八医院2016年4月-2018年4月期间收治的88例阴性症状精神分裂症患者,按随机数字表法分为对照组和试验组,试验组患者给予氨磺必利片进行治疗,对照组患者给予舒必利片进行治疗,所有患者均持续治疗12周,记录2组患者经过治疗后的日常生活质量评分,并比较2组精神分裂症患者的总有效率以及不良反应发生率。结果试验组患者经过治疗后的总有效率为84.09%,显著高于对照组患者的总有效率(63.64%),差异有统计学意义(χ^2=8.923,P<0.05)。试验组患者经过治疗后的社会功能和心理功能、躯体功能等日常生活质量评分均显著高于对照组患者,差异有统计学意义(P均<0.05)。试验组患者经过治疗后的不良反应发生率为13.64%,显著低于对照组的31.82%,差异有统计学意义(χ^2=8.384,P<0.05)。结论对于阴性症状精神分裂症患者采用氨磺必利进行治疗能够有效改善其生活质量,大大降低其不良反应发生率,治疗效果显著,值得在临床上推广应用。Objective To investigate the effect of amsulfuropride on the effective rate, quality of life and adverse reactions in patients with negative symptoms of schizophrenia. Methods Eighty-eight schizophrenic patients with negative symptoms admitted to Shijiazhuang Eighth Hospital from April 2016 to April 2018 were randomly divided into control group and experimental group. The control group was treated with sulpiride tablets, while the experimental group was treated with amisulfapride tablets. All patients were treated for 12 weeks. The daily life of the two groups after treatment was recorded. The total effective rate and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the experimental group was 84.09% after treatment, which was significantly higher than that of the control group(63.64%). The difference was statistically significant(χ^2=8.923, P<0.05). After treatment, the scores of social function, psychological function and physical function in the experimental group were significantly higher than those in the control group(P<0.05). After treatment, the incidence of adverse reactions in the experimental group was 13.64%, which was significantly lower than that in the control group(31.82%,χ^2=8.384, P<0.05). Conclusion For the patients with negative symptoms schizophrenia treated with amsulfuropride can effectively improve their quality of life, greatly reduce the incidence of adverse reactions. The treatment effect is significant, which is worth to be popularized in clinical use.

关 键 词：精神分裂症 氨磺必利 阴性症状 生活质量 临床疗效 

分 类 号：R749.3[医药卫生—神经病学与精神病学]