咖啡因联合无创呼吸支持治疗对极低出生体重儿呼吸暂停的临床价值分析  

Analysis of clinical value of caffeine combined with non-invasive respiratory support therapy for apnea in very low birth weight infants

作　　者：张丽范[1] 郭小芳[1] 赵丽娟[1] ZHANG Li-fan;GUO Xiao-fang;ZHAO Li-juan(Jiangmen Xinhui District Maternal and Child Health Hospital,Jiangmen 529100,China)

机构地区：[1]江门市新会区妇幼保健院

出　　处：《中国实用医药》2019年第21期81-82,共2页China Practical Medicine

摘　　要：目的探讨极低出生体重儿在出现呼吸暂停时采取咖啡因联合无创呼吸支持治疗的临床价值。方法选取2014年5月~2018年11月收治的55例出现呼吸暂停的极低出生体重儿作为联合组,另选取2009年4月~2014年4月收治的51例出现呼吸暂停的极低出生体重儿作为对照组。联合组患儿采取咖啡因联合无创呼吸支持治疗,对照组患儿仅采取无创呼吸支持治疗。比较两组患儿的开奶时间、呼吸机支持治疗时间及并发症发生情况。结果联合组患儿开奶时间(2.75±0.26)h、呼吸机支持治疗时间(6.63±0.57)d均明显短于对照组的(3.23±0.37)h、(7.19±0.98)d,且联合组患儿并发症发生率16.36%(9/55)明显低于对照组的58.82%(30/51),差异有统计学意义(P<0.05)。结论在极低体重儿呼吸暂停治疗中,采取咖啡因联合无创呼吸支持治疗可明显加快患儿开奶时间,缩短呼吸机支持治疗时间,降低并发症发生率,效果理想。Objective To observe the clinical value of caffeine combined with non-invasive respiratory support therapy for apnea in very low birth weight infants. Methods There were 55 very low birth weight infants with apnea received from May 2014 to November 2018 as combined group, and 51 very low birth weight infants with apnea received from April 2009 to April 2014 as control group. The combined group received caffeine combined with non-invasive respiratory support therapy, and the control group received non-invasive respiratory support. Comparison were made on time of first milking, ventilator support treatment time and occurrence of complications between the two groups. Results The combined group had obviously shorter time of first milking(2.75±0.26) h and ventilator support treatment time as(6.63±0.57) d than(3.23±0.37) h and(7.19±0.98) d in the control group. The combined group had obviously less incidence of complications as 16.36%(9/55) than58.82%(30/51) in the control group, and the difference was statistically significant(P<0.05). Conclusion Caffeine combined with non-invasive respiratory support therapy shows idea effect in very low birth weight infants with apnea, and it can obviously accelerate time of first milking, shorten time of ventilator support treatment, and reduce the incidence of complications.

关 键 词：咖啡因 无创呼吸支持 极低出生体重儿 联合治疗 呼吸暂停 

分 类 号：R722.6[医药卫生—儿科]