奥曲肽、乌司他丁联合泮托拉唑钠治疗重症急性胰腺炎的临床效果  

Clinical effect of Octreotide, Ulinastatin combined with Pantoprazole Sodium in the treatment of severe acute pancreatitis

作　　者：祁海芳 王艳玲[1] 龚莹莹[1] 杨国常 袁王喜 闫思萌[1] QI Hai-fang;WANG Yan-ling;GONG Ying-ying;YANG Guo-chang;YUAN Wang-xi;YAN Si-meng(Department of the First Digestive Internal Medicine,Zhuozhou Hospital,Hebei Province,Zhuozhou 072750,China)

机构地区：[1]河北省涿州市医院消化内一科

出　　处：《中国当代医药》2019年第21期79-82,共4页China Modern Medicine

摘　　要：目的探讨重症急性胰腺炎患者采用奥曲肽、乌司他丁联合泮托拉唑钠治疗的临床效果。方法选取2016年3月~2018年10月我院收治的60例重症急性胰腺炎患者作为研究对象,采用随机数字表法将其分为观察组和对照组,每组各30例。对照组患者入院后接受常规治疗,观察组患者在对照组的基础上给予奥曲肽、乌司他丁联合泮托拉唑钠治疗。比较两组患者的免疫指标、血清炎症因子指标、血清淀粉酶恢复正常时间、急性生理和慢性健康Ⅱ(APACHEⅡ)评分及治疗效果。结果观察组患者的临床总有效率高于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的CD4+、CD4+/CD8+水平高于对照组,CD8+水平低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)水平低于对照组,差异有统计学意义(P<0.05)。观察组患者的血清淀粉酶恢复正常时间短于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的APACHEⅡ评分低于对照组,差异有统计学意义(P<0.05)。结论重症急性胰腺炎患者采用奥曲肽、乌司他丁联合泮托拉唑钠治疗的临床效果显著,值得临床推广应用。Objective To explore the clinical effect of Octreotide and Ulinastatin combined with Pantoprazole Sodium in the treatment of severe acute pancreatitis.Methods A total of 60 patients with severe acute pancreatitis admitted to our hospital from March 2016 to October 2018 were selected as the study subjects.They were divided into the observation group and the control group according to the random number table method,30 cases in each group.Patients in the control group were treated with routine treatment,while patients in the observation group were given Octreotide,Ulinastatin and Pantoprazole Sodium on the basis of the control group.The immune index,serum inflammatory factors,serum amylase recovery time,acute physiology and chronic health evaluationⅡ(APACHEⅡ)score and therapeutic effect were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The levels of CD4+,CD4+/CD8+in the observation group after treatment were higher than those in the control group,and the level of CD8+in the observation group after treatment was lower than that in the control group,the differences were statistically significant(P<0.05).The levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),interleukin-10(IL-10)in the observation group after treatment were lower than those of the control group,the differences were statistically significant(P<0.05).The recovery time of serum amylase in the observation group was shorter than that in the control group,the difference was statistically significant(P<0.05).The APACHEEⅡscore of the observation group after treatment was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion The clinical effect of Octreotide,Ulinastatin combined with Pantoprazole Sodium in the treatment of severe acute pancreatitis is significant,which is worthy of clinical promotion and application.

关 键 词：重症急性胰腺炎 奥曲肽 乌司他丁 泮托拉唑钠 临床效果 

分 类 号：R576[医药卫生—消化系统]