养正消积胶囊联合放化疗治疗胃癌的疗效和安全性及其对患者免疫功能的影响  

Efficacy and safety of Yangzheng Xiaoji capsule combined with radiotherapy and chemotherapy in the treatment of gastric cancer and its influence on immune function

作　　者：马骥 Ma Ji(Department of Gastroenterology,the First People's Hospital of Yongkang,Yongkang,Zhejiang 321300,China)

机构地区：[1]永康市第一人民医院消化内科,浙江省321300

出　　处：《中国基层医药》2019年第16期1965-1969,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨养正消积胶囊联合放化疗治疗胃癌的疗效和安全性及其对免疫功能的影响。方法将永康市第一人民医院2016年10月至2018年10月收治的胃癌患者80例,按照随机数字表法分为两组,每组40例。对照组予常规放疗加化疗方案,即奥沙利铂、氟尿嘧啶联合亚叶酸钙常规化疗,观察组在此基础上加用养正消积胶囊。观察两组临床症状、肿瘤客观疗效、中医症状体征评分、安全性、免疫功能。结果观察组总有效率为87.5%(35/40),显著高于对照组的72.5%(29/40)(χ^2=3.52,P<0.05)。观察组缓解率、疾病控制率分别为62.5%(25/40)、87.5%(35/40),均高于对照组30.0%(12/40)、72.5%(29/40)(χ^2=4.31,P<0.05)。两组治疗前后中医症状体征评分均显著改善(均P<0.05),且治疗后观察组积分显著低于对照组(t=5.13,P<0.05)。两组化疗前后白细胞(WBC)、血红蛋白(Hb)及血小板计数(PLT)差异均无统计学意义(均P>0.05)。观察组治疗前后WBC、Hb及PLT差异均无统计学意义(t=1.24、4.15、5.27,均P>0.05),对照组治疗前后WBC、Hb及PLT差异均有统计学意义(t=4.85、3.64、3.85,均P<0.05),两组比较,观察组WBC、Hb及PLT治疗后显著高于对照组(t=6.37、4.15、5.27,均P<0.05)。观察组发生白细胞减少4例,血红蛋白下降6例,转氨酶升高6例,均显著少于对照组的8例、10例、10例(χ^2=4.26,P<0.05)。两组治疗前外周血CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平差异均无统计学意义(均P>0.05)。观察组治疗前后外周血CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平差异均无统计学意义(t=2.14、2.08、1.69、2.47,均P>0.05),对照组CD3^+、CD4^+、CD4^+/CD8^+水平显著下降(t=5.12、4.26、5.38,均P<0.05),CD8^+水平显著上升(t=3.86,P<0.05);治疗后,观察组CD3^+、CD4^+、CD8^+、CD4^+/CD4^+水平均优于对照组(t=4.79、3.52、4.28、3.61,均P<0.05)。结论养正消积胶囊联合放化疗干预可提高胃癌患者疗效,且安全性高,毒副作用无增加,并能提高胃Objective To explore the efficacy and safety of Yangzheng Xiaoji capsule combined with radiotherapy and chemotherapy in the treatment of gastric cancer and its influence on immune function.Methods From October 2016 to October 2018,80 patients with gastric cancer in the First People's Hospital of Yongkang were divided into two groups according to the random number table,with 40 cases in each group.The control group received conventional radiotherapy plus chemotherapy,namely oxaliplatin,5-fluorouracil combined with calcium leucovorin conventional chemotherapy.The observation group received Yangzheng Xiaoji capsule on the basis of the control group.The clinical symptoms,objective tumor efficacy,TCM symptoms and signs score,safety,immune function of the two group were observed.Results The total effective rate of the observation group was 87.5%,which was significantly higher than 72.5%of the control group(χ^2=3.52,P<0.05).The RR,DCR of the observation group were 62.5%,87.5%,respectively,which were significantly higher than 30.0%,72.5%of the control group(χ^2=4.31,P<0.05).The TCM symptoms and signs scores of the two groups after treatment were significantly improved compared with those before treatment(all P<0.05),which of the observation group after treatment was significantly lower than that of the control group(t=5.13,P<0.05).There were no statistically significant differences in WBC,Hb and PLT of the observation group before and after treatment(t=1.24,1.62,1.37,all P>0.05),and there were statistically significant differences in WBC,Hb and PLT of the control group before and after treatment(t=4.85,3.64,3.85,all P<0.05),and the WBC,Hb and PLT of the observation group were significantly higher than those of the control group after treatment(t=6.37,4.15,5.27,all P<0.05).In the observation group,leukopenia decreased in 4 cases,hemoglobin decreased in 6 cases and transaminase increased in 6 cases,which were significantly lower than 8 cases,10 cases and 10 cases in the control group(χ^2=4.26,P<0.05).Before treatment,th

关 键 词：胃肿瘤 放射疗法 抗肿瘤联合化疗方案 医学 中国传统 体征和症状 安全 免疫 疗效比较研究 

分 类 号：R735.2[医药卫生—肿瘤]