Twist转录因子及E钙黏蛋白在甲状腺未分化癌中的表达及其与预后的关系  

Expressions of Twist transcription factor and E-cadherin in anaplastic thyroid carcinoma and their relationship with the prognosis

作　　者：秦东广 秦彦超 薄云峰[2] Qin Dongguang;Qin Yanchao;Bo Yunfeng(Department of Head and Neck Surgery,Shanxi Provincial Cancer Hospital,Taiyuan 030013,China;Department of Pathology, Shanxi Provincial Cancer Hospital, Taiyuan 030013, China)

机构地区：[1]山西省肿瘤医院头颈外科,太原030013 [2]山西省肿瘤医院病理科,太原030013

出　　处：《肿瘤研究与临床》2019年第7期465-468,共4页Cancer Research and Clinic

摘　　要：目的探讨甲状腺未分化癌组织中Twist转录因子及E钙黏蛋白的表达及其与患者预后的相关性。方法回顾性分析山西省肿瘤医院2016年5月至2018年4月间收治的20例甲状腺未分化癌患者的临床病理资料。采用免疫组织化学法检测甲状腺未分化癌组织及相应癌旁组织中Twist蛋白及E钙黏蛋白的表达,分析两者表达与患者临床病理特征之间的关系,分析两种蛋白表达及临床病理因素与患者预后的关系。结果Twist蛋白在甲状腺未分化癌组织中的阳性表达率为65%(13/20),在癌旁组织中为20%(4/20),差异有统计学意义(P=0.004)。E钙黏蛋白在甲状腺未分化癌组织中的阳性表达率为60%(12/20),在癌旁组织中为100%(20/20),差异有统计学意义(P=0.001)。甲状腺未分化癌组织中Twist蛋白及E钙黏蛋白的表达呈负相关(r=-0.685,P=0.001)。Twist蛋白在甲状腺未分化癌中的表达与患者性别、年龄及肿瘤直径均无关(均P>0.05),与淋巴结转移及TNM分期有关(均P<0.05);E钙黏蛋白在甲状腺未分化癌中的表达与临床病理因素均无关(均P>0.05)。Kaplan-Meier生存分析结果表明,淋巴结转移(P<0.01)、TNM分期(P=0.002)及Twist蛋白表达(P=0.017)是影响患者预后的因素。结论Twist转录因子在甲状腺未分化癌中表达上调,E钙黏蛋白表达下调,其中Twist蛋白的表达与患者预后相关。上皮间质转化可能参与了甲状腺未分化癌的进展过程。Objective To investigate the expressions of Twist transcription factor and E-cadherin in anaplastic thyroid carcinoma and their correlation with the prognosis. Methods The clinicopathological data of 20 patients with anaplastic thyroid carcinoma in Shanxi Provincial Cancer Hospital from May 2016 to April 2018 were retrospectively analyzed. The expressions of Twist protein and E-cadherin protein in anaplastic thyroid carcinoma tissues and corresponding paracancerous tissues were detected by using immunohistochemistry. The relationship between the expressions of the two proteins and the clinicopathological features of the patients was analyzed, and the correlation among the expressions of the two proteins as well as the clinicopathological factors and the prognosis of the patients was analyzed. Results The positive expression rate of Twist protein in anaplastic thyroid carcinoma tissues was 65%(13/20), while it was 20%(4/20) in paracancerous tissues, and the difference was statistically significant (P=0.004). The positive expression rate of E-cadherin in anaplastic thyroid carcinoma tissues was 60%(12/20), while it was 100%(20/20) in paracancerous tissues, and the difference was statistically significant (P=0.001). There was a negative correlation between the expression of Twist protein and E-cadherin protein in anaplastic thyroid carcinoma (r=-0.685, P=0.001). The expression of Twist protein in anaplastic thyroid carcinoma was correlated with lymph node metastasis and TNM stage (both P < 0.05), while it had no correlation with gender, age and tumor diameter (all P > 0.05). The expression of E-cadherin protein in anaplastic thyroid carcinoma had no correlation with clinicopathological factors (all P >0.05). The results of Kaplan-Meier survival analysis showed that lymph node metastasis (P < 0.01), TNM stage (P=0.002) and the expression of Twist protein (P=0.017) were prognostic factors in patients with anaplastic thyroid carcinoma. Conclusions The expression of Twist transcription factor is upregulated in anaplasti

关 键 词：甲状腺未分化癌 上皮细胞-间充质细胞转换 免疫组织化学 

分 类 号：R736.1[医药卫生—肿瘤]