血清新型蛋白复合物与炎症性肠病活动度评估的关系  

Relationship between novel serum immunoinflammation-related protein complexes and disease activity evaluation in inflammatory bowel disease

作　　者：孙颖昊[1] 李骥[1] 舒慧君[1] 李智立[2] 钱家鸣[1] SUN Yinghao;LI Ji;SHU Huijun;LI Zhili;QIAN Jiaming(Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730;Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院消化内科,北京100730 [2]中国医学科学院基础医学研究所北京协和医院基础医学院生物物理及结构生物学系

出　　处：《胃肠病学和肝病学杂志》2019年第8期860-864,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：卫生行业科研专项基金项目(201002020)

摘　　要：目的探讨血清新型循环免疫炎症相关蛋白复合物(IIRPCs)水平在炎症性肠病(inflammatory bowel disease, IBD)评估中的价值。方法纳入2012年11月至2016年5月于北京协和医院门诊或住院部就诊的69例UC患者和67例CD患者,收集其完整的临床资料。收集血清,通过Native-PAGE对IIRPCs进行分离,后进行定量分析。结果对于UC患者,活动期较缓解期白蛋白水平下降,血小板、血沉和hsCRP水平升高,差异均有统计学意义( P 均<0.05)。活动期IIRPCs水平较缓解期升高,其中中度活动组b型的b2、b4、b5水平与缓解期相比,差异有统计学意义( P <0.05),重度活动组a型的a3及b型的b2、b5水平与缓解期相比,差异有统计学意义( P <0.05),b2、b5对UC疾病活动度评估的ROC曲线下面积分别为0.826、0.859。对于CD患者,活动期血红蛋白、白蛋白水平下降,血小板、血沉水平升高,差异有统计学意义( P 均<0.05),活动期IIRPCs水平较缓解期呈升高趋势,但差异无统计学意义( P >0.05)。UC患者中,IIRPCs与ESR、hsCRP呈正相关。结论 IIRPCs与IBD疾病活动度相关,活动期IBD患者血清IIRPCs水平较缓解期升高,且IIRPCs含量与传统炎症指标ESR、hsCRP呈正相关。Objective To investigate the value of serum immunoinflammation-related protein complexes (IIRPCs) in the evaluation of disease activity in inflammatory bowel disease (IBD). Methods A total of 69 UC patients and 67 CD patients who were admitted to Peking Union Medical College Hospital from Nov.2012 to May. 2016 were enrolled. Complete clinical data were collected. After regular clinical examination, serum leftovers were collected, and IIRPCs were separated by Native-PAGE and then underwent quantitative analysis. Results For UC patients, the level of albumin was decreased, the levels of platelet, erythrocyte sedimentation rate and hsCRP were increased in active group compared with remission group ( P <0.05). The levels of IIRPCs were higher in active group, levels of b2, b4 and b5 in moderately active group were statistically different compared with remission group ( P <0.05), levels of a3, b2 and b5 in severely active group were also statistically different compared with remission group ( P <0.05). For b2 and b5, the area under ROC curve were 0.826 and 0.859, respectively for disease activity evaluation. For CD patients, the levels of albumin and hemoglobin were decreased, levels of platelet and erythrocyte sedimentation rate were increased in active group ( P <0.05). The levels of IIRPCs were higher in active group, however there was no statistical difference ( P > 0.05 ). In UC patients, IIRPCs were positively correlated with ESR and hsCRP. Conclusion IIRPCs are associated with IBD disease activity. Serum levels of IIRPCs are increased in active group compared with remission group and positively correlated with ESR and hsCRP.

关 键 词：炎症性肠病 免疫炎症相关蛋白复合物 活动度 

分 类 号：R574.62[医药卫生—消化系统]