18F-FDG PET/CT半定量参数在非小细胞肺癌预后判断中的研究进展  

Research progress of semi-quantitative parameters assessed on 18F-FDG PET/CT for prognosis of non-small cell lung cancer

作　　者：殷雷[1] 廖栩鹤[1] 张建华[1] 王荣福[1] YIN Lei;LIAO Xuhe;ZHANG Jianhua;WANG Rongfu(Department of Nuclear Medicine,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院核医学科

出　　处：《中国介入影像与治疗学》2019年第8期507-510,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：国家自然科学基金(NSFC 30470498);北京大学第一医院科研种子基金(2018SF021);北京大学第一医院自然科学基金(2017QN14)

摘　　要：肺癌是目前世界上发病率最高的恶性肿瘤,非小细胞肺癌(NSCLC)约占其中的80%~85%,手术切除仍是首选治疗方法,因此,术前的准确分期和预后评估至关重要。18F-FDGPET/CT检查相关的葡萄糖代谢半定量参数,包括最大标准化摄取值(SUVmax)、最大标准化摄取峰值(SUVpeak)、平均标准化摄取值(SUVmean)、肿瘤代谢体积(MTV)、总糖酵解量(TLG)等,可为判断肿瘤预后提供重要信息。本文对以上葡萄糖代谢半定量参数判断NSCLC预后的临床进展进行综述。The incidence of lung cancer is the highest in malignant tumors worldwide, non-small cell lung cancer (NSCLC) accounts for 80%-85% of the total of lung cancer. Surgery is still the first choice for the treatment of NSCLC. Therefore, accurate preoperative staging and prognostic evaluation are essential. A series of semi-quantitative parameters,including maximum standardized uptake value (SUV max ), peak standardized uptake value (SUV peak ), mean standardized uptake value (SUV mean ), metabolic tumor volume (MTV) as well as total lesion glycolysis (TLG), which assessed on 18 F-FDG PET/CT, are convinced as a group of factors with important value for prognostic evaluation of NSCLC. The prognostic role of above glucose metabolic quantitative parameters in recent clinical application of NSCLC were reviewed in this article.

关 键 词：肺肿瘤 体层摄影术 发射型计算机 代谢 预后 

分 类 号：R734.2[医药卫生—肿瘤] R817.4[医药卫生—临床医学]