骨瓣开颅显微镜手术治疗颅内肿瘤临床观察  

Effect of craniotomy with bone flap on the efficacy of patients with intracranial tumors and the occurrence of adverse reactions

作　　者：贺艳阳[1] 周武涛[1] 徐其岭 HE Yanyang;ZHOU Wutao;XU Qiling(Department of Neurosurgery,Zhengzhou People's Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州人民医院神经外科

出　　处：《中国实用神经疾病杂志》2019年第12期1370-1376,共7页Chinese Journal of Practical Nervous Diseases

摘　　要：目的 探讨骨瓣开颅显微镜手术对颅内肿瘤患者的疗效及不良反应的影响。方法 选择2017-01—2017-12郑州人民医院治疗的颅内肿瘤患者50例,随机分为2组,对照组行传统开颅手术,研究组行骨瓣开颅显微镜手术。结果 研究组患者住院时间、术中出血量、手术时间及1a复发率均低于对照组,且研究组1a存活率高于对照组(P<0.05);研究组患者治疗后βEP、OT、AVP水平均高于对照组,IL-6、TNF-α水平均低于对照组(P<0.05);究组治疗后社会功能、躯体功能、角色功能、认知功能及情绪功能评分均高于对照组(P<0.05);研究组不良反应发生率低于对照组(P<0.05)。结论 骨瓣开颅显微镜手术治疗颅内肿瘤患者的临床效果更好,有效缩短患者住院时间、手术时间,有利于脑脊液神经肽水平的恢复,减轻炎症因子对机体的损伤,改善患者的生活质量及不良情绪,手术安全性高。Objective To investigate the effect of bone flap craniotomy on the efficacy of patients with intracranial tumors and the occurrence of adverse reactions. Methods A total of 50 patients with intracranial tumors from January 2017 to December 2017 were randomly divided into two groups.The control group underwent conventional craniotomy and the study group underwent craniotomy. Results The length of hospital stay,intraoperative blood loss,operation time and 1 year recurrence rate in the study group were lower than those in the control group,and the 1 year survival rate of the study group was higher than that of the control group ( P <0.05).The study group patients had β EP after treatment.The levels of OT and AVP were higher than those of the control group,and the levels of IL 6 and TNF α were lower than those of the control group ( P <0.05).The social function,physical function,role function,cognitive function and emotional function after treatment in the study group.The scores were higher than the control group ( P <0.05).The incidence of adverse reactions in the study group was lower than that in the control group ( P <0.05). Conclusion In the treatment of patients with intracranial tumors,craniotomy with bone flap has important application value.Compared with traditional craniotomy,the clinical effect is better,which can effectively shorten the hospitalization time and operation time of patients,and is beneficial to cerebrospinal fluid neuropeptide levels.The recovery,reduce the damage of inflammatory factors on the body,improve the quality of life of patients,improve the patient's bad mood,high surgical safety,low incidence of adverse reactions,bone flap cranioscopic surgery is worthy of application and promotion.

关 键 词：颅内肿瘤 骨瓣开颅显微镜手术 传统开颅手术 不良发应 生活质量 

分 类 号：R739.41[医药卫生—肿瘤]