四种常见受体酪氨酸激酶在胃癌中的表达及对预后的影响  

Expression level and prognostic significance of receptor tyrosine kinase in gastric cancer patients

作　　者：黄国强 黄一波 张海强[2] 许国富 HUANG Guo-qiang;HUANG Yi-bo;ZHANG Hai-qiang(Department of General Surgery,the Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou,Zhejiang 310005,China)

机构地区：[1]浙江中医药大学附属第二医院普外科,浙江杭州310005 [2]宁波大学医学院附属医院胃肠外科,浙江宁波315012 [3]浙江中医药大学附属第二医院病理科

出　　处：《中华全科医学》2019年第9期1458-1462,共5页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2015KYA170,2017KY517)

摘　　要：目的探讨表皮生长因子受体(EGFR)、肝细胞生长因子受体(c-Met)、血小板衍生生长因子受体(PDGFR)和血管内皮生长因子受体(VEGFR)在胃癌中表达及对预后影响。方法选择2012年1月-2015年8月于浙江中医药大学附属第二医院及宁波大学医学院附属医院就诊的118例胃癌患者,比较EGFR、c-Met、PDGFR和VEGFR不同表达情况下胃癌患者的临床病理差异及对预后的影响。结果 EGFR阳性组和阴性组患者的肿瘤部位、直径和pT分期间差异均无统计学意义(均P>0.05),阳性组的分化程度明显低于阴性组,pN分期明显高于阴性组(均P<0.05);c-Met阳性组和阴性组肿瘤部位和直径差异无统计学意义(均P>0.05),阳性组肿瘤分化程度明显低于阴性组,pT和pN分期明显高于阴性组(均P<0.05);PDGFR阳性组和阴性组的肿瘤部位、分化程度、肿瘤直径和pT分期间差异均无统计学意义(均P>0.05),阳性组的pN分期明显高于阴性组(P<0.05);VEGFR阳性组和阴性组的肿瘤部位、分化程度和直径差异均无统计学意义(均P>0.05),阳性组的pT和pN分期明显高于阴性组(均P<0.05)。4种指标阴性组患者的死亡风险均明显低于其阳性组(均P<0.05)。pT分期和pN分期是胃癌患者不良预后的独立危险因素。结论 EGFR、c-Met、PDGFR和VEGFR阳性表达的胃癌患者预后较差,pT分期和pN分期是胃癌患者术后不良预后的独立危险因素。Objective To explore the expression of EGFR, c-Met, PDGFR and VEGFR in gastric cancer tissues and its prognostic significance. Methods One hundred and eighteen cases gastnic cancer patients in our hospital between January 2012 to August 2015 were selected. The levels of EGFR, c-Met, PDGFR and VEGFR in gastric cancer tissues were tested. The clinical and pathological differences among the patients with different levels of receptor tyrosine kinase were studied. The influence of the levels of receptor tyrosine kinase was evaluated. Results No significant difference in tumor location, diameter and pT stage were found between EGFR positive and negative group(all P>0.05), while the differentiated degree of cells was significantly lower and pN stage was significantly high in EGFR positive group(all P<0.05). No significant difference in tumor location and tumor diameter were found between c-Met positive and negative group(all P>0.05), while differentiated degree of cells was significantly lower, pT and pN stag were significantly higher in c-Met positive group(all P<0.05). No significant difference in tumor location, differentiated degree, tumor diameter and pT stage were found between PDGFR positive and negative group(all P>0.05), while pN stage was significantly higher in PDGFR positive group(P<0.05). No significant difference in tumor location, differentiated degree and diameter were found among VEGFR positive and negative group(all P>0.05), while pT and pN stage were significantly higher in VEGFR positive group(all P<0.05). The death risk of negative group of these four index were significantly lower than the matching positive group(all P<0.05). pT stage and pN stage were risk factors for bad prognosis of gastric cancer. Conclusion The positive expression of EGFR, c-Met, PDGFR and VEGFR may result in a bad prognosis. pT stage and pN stage are the risk factors for bad prognosis of gastric cancer.

关 键 词：表皮生长因子受体 肝细胞生长因子受体 血小板衍生生长因子受体 血管内皮生长因子受体 胃癌 

分 类 号：R735.2[医药卫生—肿瘤] R730.7[医药卫生—临床医学]