猴头菌-青蒿生物转化物化学成分的研究  

Chemical constituents from the biological transformation of Hericium erinaceus and Artemisia annua

作　　者：赵小芳[1] 徐博[1] 任杰[1] 何述金 李娟[1,3] 李顺祥 ZHAO Xiao-fang;XU Bo;REN Jie;HE Shu-jin;LI Juan;LI Shun-xiang(Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Xinhui Pharmacy Co.,Ltd,Changsha 410200,China;Hunan Provincial Engineering Research Center of Bioactive Substance Discovery of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南新汇制药股份有限公司,湖南长沙410200 [3]湖南省中药活性物质筛选工程技术研究中心,湖南长沙410208

出　　处：《中成药》2019年第8期1875-1879,共5页Chinese Traditional Patent Medicine

基　　金：中药学湖南省重点学科科技项目(zy201501);湖南省研究生科研创新项目(CX2015B323);湖南中医药大学研究生一方科研创新项目(YF201703);湖南新汇制药股份有限公司资助(50010079)

摘　　要：目的研究猴头菌Hericium erinaceus(Bull.) Pers.-青蒿Artemisia annua L.生物转化物的化学成分。方法猴头菌-青蒿生物转化物75%乙醇提取物采用硅胶、Sephadex LH-20凝胶柱、重结晶进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到10个化合物,分别鉴定为5α-豆甾-3-酮(1)、(22E, 24R)-啤酒甾醇(2)、3α-羟基脱氧青蒿素(3)、异莨菪亭(4)、nodakenetin(5)、(+)-lomatin(6)、(+)-tert-O-methylbyakangelicin(7)、5, 7, 4′-三羟基-3′, 5′-二甲氧基黄酮(8)、蒿黄素(9)、quercetagetin-3, 7, 3′, 4′-tetramethyl ether(10)。结论化合物5~7为首次从猴头菌丝体和青蒿药材中分离得到。AIM To study the chemical constituents from the biological transformation of Hericium erinaceus(Bull.) Pers. and Artemisia annua L..METHODS The 75% ethanol extract from H. erinaceus and A. annua biological transformation was isolated and purified by silica, Sephadex LH-20 and recrystallization,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Ten compounds were isolated and identified as 5α-stigmasta-3-one(1), cerevisterol(2), 3α-hydroxydeoxyartemisinin(3), isoscopoletin(4), nodakenetin(5),(+)-lomatin(6),(+)-tert-O-methylbyakangelicin(7), tricin(8), artemein(9), quercetagetin-3, 7, 3′, 4′-tetramethyl ether(10).CONCLUSION Compounds 5-7 are isolated from H. erinaceus and A. Annua for the first time.

关 键 词：猴头菌 青蒿 生物转化物 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]