保留生育功能治疗对年轻卵巢交界性肿瘤患者术后复发及妊娠的影响  

Effects of fertility function-preserving therapy on postoperative recurrence and pregnancy in young patients with borderline ovarian tumor

作　　者：李涛 杜丹丽[2] 杜世华[1] 桑琳[1] LI Tao;DU Dan-li;DU Shi-hua;SANG Lin(Department of Gynecology and Obstetrics,Hefei Second People′s Hospital of Anhui Province,Hefei 230000,China;Department of Gynecology and Obstetrics,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China)

机构地区：[1]安徽省合肥市第二人民医院妇产科,合肥市230000 [2]蚌埠医学院第一附属医院妇产科,安徽省蚌埠市233004

出　　处：《广西医学》2019年第13期1638-1641,共4页Guangxi Medical Journal

摘　　要：目的探讨保留生育功能治疗对年轻卵巢交界性肿瘤患者术后复发及妊娠的影响。方法回顾性分析49例保留生育功能治疗的年轻卵巢交界性肿瘤患者临床资料,分析其术后复发及妊娠情况。比较不同保留生育功能手术方式或不同术后治疗方式患者术后复发率、妊娠率以及复发与非复发患者的临床病理特征。结果不同保留生育功能手术方式或不同术后治疗方式的患者间术后妊娠率及复发率比较,差异均无统计学意义(均P>0.05)。复发组术前糖类抗原125(CA125)水平≥5.0 IU/mL、国际妇产科联盟分期Ⅰ期、黏液性卵巢交界性肿瘤的患者比例均高于非复发组,但差异均无统计意义(均P>0.05)。结论不同保留生育功能手术方式及术后是否化疗,可能对年轻卵巢交界性肿瘤患者术后妊娠及复发无明显影响。对于术前CA125水平高的卵巢交界性肿瘤患者,应警惕保留生育功能手术后复发的可能。Objective To investigate the effects of fertility function-preserving therapy on postoperative recurrence and pregnancy in young patients with borderline ovarian tumor. Methods The clinical data of 49 young patients with borderline ovarian tumor who received fertility function-preserving therapy were retrospectively analyzed,and their postoperative recurrence and pregnancy status were analyzed.Postoperative recurrence rate and pregnancy rate were compared among patients with different surgical approaches for fertility function preservation,or with different postoperative treatment methods,and clinicopathological characteristics were compared between the recurrent and non-recurrent patients. Results There was no statistically significant difference in postoperative pregnancy rate or recurrence rate among patients with different surgical approaches for fertility function preservation,or with different postoperative treatment methods(all P >0.05).The recurrent group exhibited a higher proportion of cases having a preoperative carbohydrate antigen 125(CA125) level ≥5.0 IU/mL,the International Federation of Gynecology and Obstetrics staging system stage Ⅰ tumor,or borderline serous ovarian tumor compared with the non-recurrent group,but exhibiting no statistically significant difference(all P >0.05). Conclusion Different fertility function-preserving surgical approaches and postoperative chemotherapy may have no significant effects on postoperative pregnancy or recurrence in young patients with borderline ovarian tumor.Patients suffering from borderline ovarian tumor with a high preoperative CA125 level should be alert to the possibility of recurrence after fertility function-preserving surgery.

关 键 词：卵巢交界性肿瘤 保留生育功能 复发 妊娠 

分 类 号：R737.31[医药卫生—肿瘤]