丁苯酞注射液序贯丁苯酞胶囊治疗急性脑梗死后认知功能障碍的临床效果  

Clinical effect of Butylphthalide Injection sequential Butylphthalide Capsules in the treatment of cognitive dysfunction after acute cerebral infarction

作　　者：梁群娣[1] 吴文军[1] 郑静红[1] LIANG Qun-di;WU Wen-jun;ZHENG Jing-hong(Department of Neurology,Zhongshan People′s Hospital,Guangdong Province,Zhongshan 528400,China)

机构地区：[1]广东省中山市人民医院神经内科

出　　处：《中国当代医药》2019年第22期51-54,共4页China Modern Medicine

基　　金：广东省中山市医学科研项目(2018A020320

摘　　要：目的探讨丁苯酞注射液序贯丁苯酞胶囊治疗急性脑梗死后认知功能障碍的临床效果。方法选取2017年10月~2018年10月在我院神经内科治疗的80例急性脑梗死后认知功能障碍患者作为研究对象,按照用药方案的不同将其分为对照组与观察组,每组各40例。对照组患者采用常规药物治疗,观察组在常规药物的基础上采用丁苯酞注射液序贯丁苯酞胶囊治疗。比较两组患者的临床疗效、治疗前后简易精神状态量表(MMSE)、蒙特利尔认知评估量表(MOCA)、美国国立卫生研究院卒中量表(NIHSS)、日常生活能力量表(ADL)评分及超敏C反应蛋白(hs-CRP)、五聚素-3(PTX-3)、超氧化物歧化酶(SOD)水平。结果观察组患者的治疗总有效率为95.00%,明显高于对照组的75.00%,差异有统计学意义(P<0.05)。观察组患者治疗后2周、3个月的MMSE、MOCA评分均明显高于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后2周、3个月的NIHSS、ADL评分均明显低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的hs-CRP、PTX-3水平均明显低于对照组,SOD水平明显高于对照组,差异有统计学意义(P<0.05)。结论丁苯酞注射液序贯丁苯酞胶囊治疗急性脑梗死后认知功能障碍的临床效果显著,能有效抑制炎性因子,对抗过氧化损伤,改善脑神经功能,促进生活质量的提高,具有积极的临床意义。Objective To investigate the clinical effect of Butylphthalide Injection sequential Butylphthalide Capsules in the treatment of cognitive dysfunction after acute cerebral infarction.Methods Eighty patients with cognitive dysfunction after acute cerebral infarction treated in neurology department of our hospital from October 2017 to October 2018 were selected as the study subjects.They were divided into control group and observation group according to different medication regimens,40 cases in each group.The patients in the control group were treated with conventional drugs,and patients in the observation group was treated with Butylphthalide Injection sequential Butylphthalide Capsules on the basis of conventional drugs.The clinical efficacy,the mini-mental state scale (MMSE),the Montreal cognitive assessment scale (MOCA),the national institutes of health stroke scale (NIHSS),the daily living ability scale (ADL) scores and the levels of high-sensitivity C-reactive protein (hs-CRP),pentameric-3 (PTX-3),superoxide dismutase (SOD) before and after treatment were compared between the two groups.Results The total effective rate of the treatment in the observation group was 95.00%,which was significantly higher than that in the control group (75.00%),and the difference was statistically significant (P<0.05).The MMSE and MOCA scores of the observation group at 2 weeks and 3 months after treatment were significantly higher than those of the control group,and the differences were statistically significant (P<0.05).The NIHSS and ADL scores of the observation group at 2 weeks and 3 months after treatment were significantly lower than those of the control group,and the differences were statistically significant (P<0.05).The levels of hs-CRP and PTX-3 in the observation group at 2 weeks and 3 months after treatment were significantly lower than those in the control group,the SOD level was significantly higher than that in the control group,and the differences were statistically significant (P<0.05).Conclusion The clinical effe

关 键 词：急性脑梗死 认知功能障碍 丁苯酞注射液序贯丁苯酞胶囊 临床疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]