外周血中性粒细胞与淋巴细胞比值评估广泛期小细胞肺癌患者预后的价值研究  

Prognostic value of peripheral blood neutrophil and lymphocyte ratio in patients with extensive small cell lung cancer

作　　者：邱野[1] 江玉兰 江茂琼 李婷[1] 江健[1] 贾钰铭[1] Qiu Ye;Jiang Yulan;Jiang Maoqiong;Li Ting;Jiang Jian;Jia Yuming(Department of Oncology, N0.2 People's Hospital, Yibin,Sichuan 644000, China;North Sichuan Medical College, Nanchong,Sichuan 637000, China)

机构地区：[1]宜宾市第二人民医院肿瘤科,四川宜宾644000 [2]川北医学院,四川南充637000

出　　处：《医药前沿》2019年第19期32-33,共2页Journal of Frontiers of Medicine

摘　　要：目的:分析外周血中性粒细胞与淋巴细胞比值(NLR)在广泛期小细胞肺癌患者预后评估中的应用价值.方法:选取我院近三年(2015年9月-2018年10月)收治的60例广泛期小细胞肺癌患者,所有患者能耐受并且完成至少6个周期的一线含铂类化疗治疗方案,化疗前测量血常规,同时对NLR进行计算.以NLR值达到3.86作为界值,将本组患者分为低NLR组(n=33)和高NLR组(n=27),对两组患者预后情况进行分析和对比.结果:低NLR组患者中位生存期(18.92±3.58)个月显著高于高NLR组患者(13.52±2.78)个月;高NLR组中患者年龄>60岁、局限期、KPS评分>70分、吸烟<400年/支中位生存期显著低于低NLR组(P<0.05);多因素分析结果证实,年龄、临床分期、NLR是影响广泛期小细胞肺癌患者预后的独立危险因素,值得临床关注.结论:外周血中性粒细胞与淋巴细胞比值(NLR)与广泛期小细胞肺癌患者生存期存在一定关系,随着研究的不断深入,NLR有望成为判断广泛期小细胞肺癌患者预后的参考指标.Objective To evaluate the prognostic value of peripheral blood neutrophil / lymphocyte ratio (NLR) in patients with extensive small cell lung cancer (SCLC). Methods The clinical data of 60 patients with extensive small cell lung cancer from September 2015 to October 2018 in the hospital were analyzed retrospectively All patients were able to tolerate and complete a first-line platinumcontaining chemotherapy regimen for at least six cycles. Blood routine was measured before chemotherapy and NLR was calculated at the same time. The patients were divided into low NLR group (n=42) and high NLR group (n=4) with NLR value of 3. 86 as the cut-off value. The prognosis of group 2 patients was analyzed and compared in the group of NLR (n=18). Results The median survival of patients with low NLR (18.92-3.58) months was significantly higher in the NLR group (13.52-2.78) months;in the high-NLR group, the age of the patients was> 60 years, the limit period and the KPS score were more than 70 points, and the median survival time of the patients with smoking was lower than that of the low NLR group (P <0.05);The results of multi-factor analysis confirm that the age, clinical stage and NLR are independent risk factors that affect the prognosis of patients with small cell lung cancer Conclusion The peripheral blood is neutral The ratio of granulocyte to lymphocyte (NLR) has a certain relationship with the survival time of patients with extensive small cell lung cancer With the deepening of the study NLR is expected to be a reference index for predicting the prognosis of patients with extensive small cell lung cancer.

关 键 词：外周血 中性粒细胞 淋巴细胞 广泛期小细胞肺癌 

分 类 号：R730.5[医药卫生—肿瘤]