脑梗死患者血清CXCL-16、GDF-15、PLA2水平变化及意义  

Clinical significance of serum CXCL-16, GDF-15 and PLA2 in patients with cerebral infarction

作　　者：刘希奇[1] 李孝庆 姚彦 崔亚男 Xi-qi Liu;Xiao-qing Li;Yan Yao;Ya-nan Cui(Department of Neurology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, China;Department of Neurosurgery, Cangzhou People's Hospital, Cangzhou, Hebei 061000, China;Department of Ultrasound, Cangzhou Central Hospital, Cangzhou, Hebei 061001, China)

机构地区：[1]沧州市中心医院神经内五科,河北沧州061001 [2]沧州市人民医院神经外科,河北沧州061000 [3]沧州市中心医院超声科,河北沧州061001

出　　处：《中国现代医学杂志》2019年第15期36-40,共5页China Journal of Modern Medicine

基　　金：沧州市重点研发计划指导项目(No:172302160)

摘　　要：目的 研究脑梗死患者的血清CXC趋化因子16(CXCL-16)、血清生长分化因子15(GDF-15)、脂蛋白相关磷脂酶A2(PLA2)的水平变化及对脑梗死患者临床诊治的指导意义.方法 选取2016年6月—2017年6月沧州市中心医院98例脑梗死患者为观察组,同期该院进行体检的50例健康志愿者作为对照组.所有受试者于入院时抽血检测各组的CXCL-16、GDF-15、PLA2、C反应蛋白(CRP)水平,综合评价脑梗死患者各项指标的水平变化及对临床诊断的意义.结果 ①观察组患者的CXCL-16、GDF-15、PLA2、CRP水平与对照组比较,差异有统计学意义(P<0.05).②将观察组患者按美国国立卫生院神经功能缺损评分(NIHSS)分组,患者的CXCL16、GDF-15、PLA2水平随着NIHSS分值的增加而升高,组间比较,差异有统计学意义(P<0.05),而各组间的CRP水平差异无统计学意义(P>0.05).③将患者按病灶大小分组,患者的CXCL16、GDF-15、PLA2水平随病灶的增大而升高(P<0.05),而各组间的CRP水平差异无统计学意义(P>0.05).④观察组患者治疗后出院时的CXCL-16、GDF-15、PLA2、CRP水平与对照组比较,差异无统计学意义(P>0.05),观察组患者的这些指标水平降至正常水平.结论 CXCL-16、GDF-15、PLA2水平随患者病情程度的变化而改变,可作为预测脑梗死患者发病、病情评估及判断预后的生物学标志物.Objective To study the clinical significance of serum CXC-16, Growth differentiation factor serum-15(GDF-15), lipoprotein associated phospholipase A2(PLa2) level in patients with cerebral infarction.Methods A total of 98 patients with cerebral infarction who were admitted in our hospital during June 2016 to June-2017 were enrolled in the observation group, and 50 healthy volunteers were selected as the control group. Serum levels of CXCL16, GDF-15, PLA2, C-reactive protein, and comprehensive evaluation index were recorded. Results The levels of CXCL-16, GDF-15, PLA2 and CRP were higher significantly in the observation group than those in the control group(P < 0.05). CXCL16, GDF-15, and PLA2 were positively correlated with elevated level of National Institutes of Health Stroke score(NIHSS)(P < 0.05). The levels of CXCL16, GDF-15 and PLA2 were positively correlated with increase of lesion size. No obvious difference in levels of CXCL-16, GDF-15, PLA2 or CRP were observed between observation group and control group(P > 0.05). Conclusions The levels of CXCL-16, GDF-15 and PLA2 may be a reliable biomarker for diagnosis and prognosis.

关 键 词：脑梗死/脑梗塞 血清CXC趋化因子16/趋化因子类 生长/分化因子-15 磷脂酶A 

分 类 号：R743.3[医药卫生—神经病学与精神病学]