食管鳞癌中TOP2A蛋白的表达与临床预后的关系  

Correlation studies between TOP2A expression and prognosis in esophageal carcinoma

作　　者：李宾[1] 王忠民[1] 陈志军[1] 董成来 曹克鑫 甘绍印 陶义鹏[1] LI Bin;WANG Zhongmin;CHEN Zhijun;DONG Chenglai;CAO Kexin;GAN Shaoyin;TAO Yipeng(Department of Chest Surgery,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院胸外一科

出　　处：《实用医学杂志》2019年第16期2607-2610,共4页The Journal of Practical Medicine

基　　金：河南省卫生和计划生育委员会项目(编号：2018020366)

摘　　要：目的通过检测食管癌组织中TOP2A蛋白的表达,探讨其与食管癌患者预后之间的关系。方法采用免疫组织化学方法研究TOP2A蛋白在98例食管癌标本中的表达水平,并分析其临床病理特征与食管鳞癌患者5年生存率之间的关系。结果TOP2A蛋白在98例食管癌组织及55例癌旁组织中的阳性率分别为47.9%和23.6%;采用Kaplan-Meie(K-M)法进行单因素分析并计算生存率,COX风险比例模型进行多因素分析,结果显示分化程度、淋巴结转移、临床分期及TOP2A表达是临床预后的独立危险因素,TOP2A表达阳性患者的5年生存率为19%,而TOP2A表达阴性患者的5年生存率为25%。结论TOP2A在食管鳞癌中的表达增高,且与食管癌的发生发展、侵袭转移关系密切,TOP2A表达、分化程度、淋巴结转移及临床分期是影响食管鳞癌患者远期预后的主要因素。Objective Investigation of the correlation between expression of TOP2 A and prognosis in human esophageal carcinoma by immunohistochemical staining analysis with the aim of evaluating the feasibility for TOP2 A as an prognosis marker of esophageal carcinoma.Methods The expression levels of TOP2 A in 98 samples of patients with esophageal carcinoma were detected using immunohistochemical method and its correlation with clinical pathological characteristics and prognosis was analyzed.Results The positive rates of TOP2 A in 98 cases of esophageal carcinoma tissue and 55 cases of tissue adjacent to carcinoma were 47.9%and 23.6%respectively.The Kaplan-Meier(K-M)method was applied for univariate analysis and COX regression model was applied for multivariate analysis.The yield results showed that TOP2 A expression,differentiation degree,lymph node metastasis and clinical stage were independent factors of prognosis(P<0.05).The five-year survival rate of patients with TOP2 A positive was 19%;The five-year survival rate of patients with TOP2 A negative was 25%.Conclusion The elevated TOP2 A expression level in esophageal carcinoma has a potential correlation with invasion of the esophageal carcinoma,development and transfer.TOP2 A expression,differentiation degree,lymph node metastasis and clinical stage are the main factors that contributes to the prognosis of patients with esophageal carcinoma.

关 键 词：食管癌 TOP2A 免疫组织化学 5年生存率 

分 类 号：R735.1[医药卫生—肿瘤]