MicroRNAs在肝母细胞瘤诊断、鉴别诊断及预后评估中的研究进展  

Research advances of MicroRNAs in the diagnosis,differential diagnosis and prognostic evaluation of hepatoblastoma

作　　者：成英杰 单慈 石寒菡 顾松[1] Cheng Yingjie;Shan Ci;Shi Hanhan;Gu Song(Department of Oncological Surgery,Affiliated Shanghai Children's Medical Center,Medical School of Shanghai Jiao Tong University,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心普外科

出　　处：《临床小儿外科杂志》2019年第8期660-663,共4页Journal of Clinical Pediatric Surgery

基　　金：国家临床重点专科建设项目(编号:国卫办医函[2013]544号);上海市科学技术委员会医学引导(编号:134119a7600);上海交通大学“医工交叉研究基金”(编号:YG2015MS36)

摘　　要：肝母细胞瘤(hepatoblastoma,HB)在儿童恶性肿瘤中较为罕见,多见于5岁以下儿童,男性较多见,约占儿童原发性肝脏恶性肿瘤的80%。其中仅95%的肝母细胞瘤存在甲胎蛋白(α-fetoprotein,AFP)异常升高,而且与病理类型、肿瘤分期等相关性不大。仅通过异常升高的AFP水平进行肝母细胞瘤诊断、鉴别诊断及预后评估存在一定的局限性。目前已有诸多研究发现miRNAs在HB的发生、发展中起重要作用,且具有高度组织特异性、保守性和时序性,在不同病理类型的HB中mRNAs呈特异性表达。因此,有望联合AFP与microRNAs进行HB的分子分型,组成HB的分子指纹,用于肝母细胞瘤诊断、鉴别诊断及预后评估,具有重要的参考意义。As an extremely rare type of pediatric malignant carcinoma,hepatoblastoma (HB) is commonly found in boys aged under 5 years.It accounts for proximately 80% of primary malignant hepatic tumors in children.An abnormal elevation of α-fetoprotein (AFP) occurred only in 95% of HB children.And it was not significantly correlated with pathological type or tumor staging.There is some limitation for making the diagnosis,differential diagnosis and prognostic evaluation of hepatoblastoma merely through an abnormal elevation of AFP level.As demonstrated by many studies,playing important roles in the occurrence and development of HB,miRNAs had high levels of tissue specificity,conservatism and sequence and were specifically expressed in different pathological types of HB.Thus hopefully a combined biomarker of AFP and microRNAs may be utilized for molecular typing of HB.And HB fingerprint shall provide vital references for the diagnosis,differential diagnosis and prognostic evaluation of HB.

关 键 词：肝母细胞瘤 MICRORNAS 生物学标记物 分子分型 诊断 预后评估 

分 类 号：R735.7[医药卫生—肿瘤] R730.45[医药卫生—临床医学]