儿童胃肠道间质瘤3例报告并文献复习  

Clinical analysis of diagnosing and treating gastrointestinal stromal tumors in children

作　　者：孙俊杰[1,2] 舒曼 高鹏飞[1] 蒋宏[1] 刘钧澄[1] 周李[1] Sun Junjie;Shu Man;Gao Pengfei;Jiang Hong;Liu Juncheng;Zhou Li(Department of Pediatric Surgery,First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China;Department of Urology Surgery,Municipal Children's Hospital,Shenzhen 518038,China;Department of Pathology,First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院小儿外科,广东省广州市510080 [2]深圳市儿童医院泌尿外科,广东省深圳市518038 [3]中山大学附属第一医院病理科,广东省广州市510080

出　　处：《临床小儿外科杂志》2019年第8期707-710,共4页Journal of Clinical Pediatric Surgery

摘　　要：目的分析儿童胃肠道间质瘤的临床特点并总结其诊治策略。方法回顾性分析近5年中山大学附属第一医院收治的3例胃肠道间质瘤患儿的临床资料,并结合国内外资料进行文献复习。结果3例患儿,男童1例,女童2例,分别为9岁、11岁和15.6岁;临床表现为头晕乏力、面色苍白、排黑便及腹痛等;胃镜可见胃部黏膜下肿物并出血,腹部CT提示胃小弯侧软组织占位;手术方法为胃部分切除或转移瘤切除术;3例患儿术后均口服酪氨酸激酶抑制剂治疗;随访10~48个月,1例复发,并再次接受手术,其余2例无复发。结论儿童胃肠道间质瘤临床极为罕见,以野生型为主;胃镜及腹部CT检查有助于诊断,治疗以手术为主综合治疗。Objective To summarize the clinical characteristics,diagnosis and treatment of gastrointestinal stromal tumors in children. Methods Three children diagnosed as gastrointestinal stromal tumors were admitted over the last five years.Retrospective analysis was performed for clinical data of 3 cases along with a review of related literature studies. Results There were 1 boy and 2 girls with a median age of 12 years.Their clinical manifestations included dizziness,fatigue,pale complexion,melena and abdominal pain.Endoscopy revealed submucosal tumor with hemorrhage and abdominal computer tomography (CT) hinted at an occupation of soft mass at the lesser gastric curvature.Surgical options were partial gastrectomy and metastatic tumor resection;All 3 cases received tyrosine kinase inhibitors post-operation.During a follow-up period of 10-48 months,1 recurrent case was re-operated while the remainder was uneventful. Conclusion Pediatric gastrointestinal stromal tumors are extremely rare and most cases belong to wild-type.Both gastroscopy and abdominal CT are helpful for reaching a definite diagnosis.Comprehensive therapy is essential and surgery remains a major treatment.

关 键 词：儿童 胃肠道间质瘤/诊断 胃肠道间质瘤/治疗 野生型 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]