化疗诱发口腔黏膜炎的危险因素分析  

Analysis of Risk Factors of Chemotherapy-induced Oral Mucositis

作　　者：李庆福[1] 李锡清[2] 姜丽[3] 马欣[1] LI Qingfu;LI Xiqing;JIANG Li;MA Xin(Center of Stomatology,Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Oncology,Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Hematology,Henan Provincial People's Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院口腔医学中心,河南郑州450003 [2]河南省人民医院肿瘤内科,河南郑州450003 [3]河南省人民医院血液内科,河南郑州450003

出　　处：《口腔医学研究》2019年第8期810-813,共4页Journal of Oral Science Research

基　　金：河南省科技厅项目(编号:142300410371)

摘　　要：目的:探讨化疗诱发口腔黏膜炎的危险因素。方法:通过对205例恶性肿瘤需行化疗的患者的临床资料进行回顾分析,探讨患者的年龄、性别、肿瘤类型、含氟尿嘧啶(5-FU)的化疗方式、化疗强度、化疗周期、口腔急慢性疾病、口腔卫生状况、中性粒细胞数、血红蛋白水平、和是否伴有糖尿病等因素与化疗性口炎发生的相关性。结果:单因素结果分析显示化疗方式、化疗强度、化疗周期、口腔急慢性疾病、口腔卫生状况和中性粒细胞水平的比较差异具有统计学意义。进一步多因素分析显示化疗药物的强度(β=1.099,P<0.05)、化疗周期(β=0.964,P<0.05)、化疗方式(β=1.100,P<0.05)、口腔急慢性疾病(β=1.180,P<0.05)、中性粒细胞数(β=1.050,P<0.05)是导致化疗性口炎的主要因素。结论:化疗药物的强度和周期、化疗方式、口腔急慢性疾病和中性粒细胞水平是导致化疗性口炎的危险因素。Objective:To explore the risk factors of oral mucositis induced by chemotherapy.Methods:Through retrospective analyzing the clinical data of 205 cases of malignant tumor patients who performed chemotherapy,we discussed the correlation between chemotherapy stomatitis and patient's age,sex,tumor type,containing fluorouracil (5-FU) way of chemotherapy,the strength of chemotherapy,chemotherapy cycle,oral acute or chronic disease,oral hygiene status,the number of neutrophils,hemoglobin level,and whether associated with diabetes.Results:Univariate analysis showed that there were statistically significant differences in chemotherapy,intensity of chemotherapy,duration of chemotherapy,oral diseases,oral hygiene,and neutrophil levels.Further multivariate analysis showed that the intensity of chemotherapy drugs (β=1.099,P <0.05),duration of chemotherapy (β= 0.964,P <0.05),mode of chemotherapy (β=1.100,P <0.05),acute and chronic diseases of the oral cavity (β= 1.180,P <0.05),and number of neutrophils (β=1.050,P <0.05) were the main factors leading to chemotherapeutic stomatitis.Conclusion:The intensity and cycle of chemotherapeutic drugs,chemotherapy regimens,oral acute and chronic diseases,and neutrophil levels were risk factors for chemotherapeutic stomatitis.

关 键 词：化疗 口腔黏膜炎 危险因素 回顾性研究 

分 类 号：R730.53[医药卫生—肿瘤] R781.5[医药卫生—临床医学]