CD64指数和可溶性髓系细胞触发受体1对结肠癌术后感染的诊断价值  

Value of CD64 and soluble triggering receptor expressed on myeloid cells in diagnosis of postoperative infection in colon cancer patients

作　　者：张璐 张莉[2] 李昌平[1] ZHANG Lu;ZHANG Li;LI Chang-ping(The Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China)

机构地区：[1]西南医科大学附属医院消化内科,四川泸州646000 [2]四川省医学科学院·四川省人民医院老年科,四川成都610072

出　　处：《中华医院感染学杂志》2019年第14期2162-2166,共5页Chinese Journal of Nosocomiology

基　　金：四川省医药科技计划基金资助项目(2015KWA075)

摘　　要：目的探讨CD64指数、可溶性髓系细胞触发受体1(sTREM-1)、C-反应蛋白/白蛋白(CRP/Alb)比值检测及三者联合检测在结肠癌术后感染中的诊断价值。方法本研究分为感染组、非感染组、对照组,检测三组CD64指数、sTREM-1、CRP/Alb比值水平,受试者工作特征曲线(ROC)评价血清CD64指数、sTREM-1、CRP/Alb比值及三者联合检测对结肠癌术后感染的诊断价值。结果与对照组、非感染组相比,感染组CD64指数、sTREM1、CRP/Alb比值水平显著升高(P<0.05);CD64指数、sTREM-1、CRP/Alb比值水平均是影响结肠癌术后感染的影响因素;CD64指数、sTREM-1、CRP/Alb比值预测结肠癌术后感染的曲线下面积分别为0.859(敏感度为88.7%,特异性为86.8%)、0.906(敏感度为92.5%,特异性为89.5%)、0.894(敏感度为88.7%,特异性为92.1%);三者联合检测预测结肠癌术后感染曲线下面积为0.978(敏感度为94.7%,特异性为96.2%)。结论 CD64指数、sTREM-1、CRP/Alb比值三者联合检测可提高结肠癌患者术后感染的诊断效果。OBJECTIVE To explore the value of CD64, soluble triggering receptor expressed on myeloid cells(sTREM-1), and C-reactive protein/albumin(CRP/Alb) ratio as well as the joint detection of the three indexes in diagnosis of postoperative infection in patients with colon cancer. METHODS The patients with colon cancer were divided into the infection group, the non-infection group and the control group. The levels of CD64, sTREM-1 and CRP/Alb ratio of the three groups were detected. The value of serum CD64, sTREM-1 and CRP/Alb ratio as well as the joint detection of the three indexes in diagnosis of postoperative infection in the colon cancer patients was evaluated by using receiver operating characteristic(ROC) curve. RESULTS The levels of CD64, sTREM-1 and CRP/Alb ratio of the infection group were significantly higher than those of the control group and the non-infection group(P<0.05). The levels of CD64, sTREM-1 and CRP/Alb ratio were the influencing factors for the postoperative infection in the patients with colon cancer. The areas under curve of CD64, sTREM-1 and CRP/Alb ratio were respectively 0.859, 0.906 and 0.894 in prediction of postoperative infection in the colon cancer patients;the sensitivities of CD64, sTREM-1 and CRP/Alb ratio were respectively 88.7%, 92.5% and 88.7%;the specificities were respectively 86.8%, 89.5% and 92.1%. The area under curve of the joint detection of the three indexes was 0.978 in prediction of the postoperative infection in the colon cancer patients, the sensitivity 94.7%, the specificity 96.2%. CONCLUSION The joint detection of CD64, sTREM-1 and CRP/Alb ratio may improve the effect of diagnosis of postoperative infection in the colon cancer patients.

关 键 词：结肠癌 CD64指数 可溶性髓系细胞触发受体1 C反应蛋白/白蛋白比值 早期诊断 

分 类 号：R735.35[医药卫生—肿瘤]