舒缓型光动力疗法的研究进展  

Research progress in metronomic photodynamic therapy

作　　者：石霞飞 李迎新[1] 金文东[1] 阴慧娟[1] Shi Xiafei;Li Yingxin;Jin Wendong;Yin Huijuan(Institute of Biomedical Engineering,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300192,China)

机构地区：[1]中国医学科学院北京协和医学院生物医学工程研究所,天津300192

出　　处：《国际生物医学工程杂志》2019年第3期268-275,共8页International Journal of Biomedical Engineering

摘　　要：舒缓型光动力疗法(mPDT)是近年来备受关注的一种新型光动力疗法(PDT),其与传统PDT有着相近的治疗机理,即光敏药物在特定波长光的照射下,与组织氧发生光化学反应,生成具有细胞毒性的活性氧(ROS)物质,从而选择性杀伤快速增殖的肿瘤细胞.与传统PDT不同,mPDT中的光敏药物和光是以长时间、低速率连续传输的方式,通过细胞凋亡来提高肿瘤治疗的特异性.对现有的mPDT体内外效应和机制的研究,以及用于体内研究的光敏药物和光源的研究现状进行详细的综述,以期对现有mPDT技术有一定程度的理解并为其后续研究提供参考,为推进mPDT的临床研究和应用建立基本依据.Metronomic photodynamic therapy (mPDT) is a new type of photodynamic therapy (PDT) that has received much attention in recent years.It has a similar therapeutic mechanism to traditional PDT,i.e.the photosensitizer is irradiated by visible light irradiation with a specific wavelength,and tissue oxygen photochemical reactions produce cytotoxic reactive oxygen species (ROS) that selectively kill rapidly proliferating tumor cells.Unlike traditional PDT,the photosensitizer and light in mPDT are continuously transmitted at a low time and at a low rate,and the specificity of tumor treatment is enhanced by apoptosis.In this paper,the current researches on the in vitro and in vivo effects and mechanisms of mPDT,as well as the research status of photosensitizers and light sources for in vivo research,were reviewed,with a view to understanding the existing mPDT technology and providing reference for the further studies.This review paper can provide a basic for promoting the clinical research and application of mPDT.

关 键 词：舒缓型光动力疗法 光敏药物 光源 脑肿瘤 5-氨基酮戊酸 

分 类 号：R730.5[医药卫生—肿瘤]