肾母细胞瘤基因1及其编码蛋白与肿瘤关系的研究进展  

Research progress on the relationship among Wilms’ tumor-1 gene and its coding proteins and tumor

作　　者：宋天亮[1] 韩志坚 陈昊[1] 李玉民 Song Tianliang;Han Zhijian;Chen Hao;Li Yumin(Department of Oncological Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China;Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou 730030, China)

机构地区：[1]兰州大学第二医院肿瘤外科,730030 [2]甘肃省消化系肿瘤重点实验室,兰州730030

出　　处：《中华实验外科杂志》2019年第8期1495-1498,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金面上项目(31770537).

摘　　要：肾母细胞瘤基因1(WT1)最早被发现于儿童肾母细胞瘤(Wilms瘤)患者,且被认为是抑癌基因.此后证实WT1表达异常与泌尿生殖系统发育异常造成的很多疾病有关,且在白血病、肺癌、乳腺癌、胰腺癌等多种恶性肿瘤中被证实是癌基因.本研究对WT1及其编码蛋白在肿瘤中的作用以及靶向WT1的肿瘤免疫治疗等方面的研究进展进行综述.Wilms’ tumor-1 gene (WT1) was first discovered in children with Wilms tumor and considered as a tumor suppressor gene. Since then, it has been confirmed that the abnormal expression of WT1 was related to many urinary and reproductive system diseases. And WT1 has been proved to be an oncogene in leukemia, lung cancer, breast cancer, pancreatic cancer and other malignant tumors. In this study, the role of WT1 and its coding proteins in tumor and tumor immunotherapy targeting WT1 were reviewed.

关 键 词：肾母细胞瘤基因1蛋白 白血病 恶性肿瘤 免疫治疗 

分 类 号：R737.11[医药卫生—肿瘤]