丹红注射液联合曲克芦丁治疗急性脑梗死的疗效及对hs-CRP、TNF-α和IL-6影响  

Effect of Danhong Injection Combined with Tricloxine on Acute Cerebral Infarction and Its Effects on hs-CRP, TNF-α and IL-6

作　　者：李菊琴 代青湘[1] 韩吉祥[1] 常琼[1] 李英莲[1] LI Juqin;DAI Qingxiang;HAN Jixiang;CHANG Qiong;LI Yinglian(Department of Geriatrics,The Affiliated Hospital of Qinghai University,Xining 810000,Qinghai,China)

机构地区：[1]青海大学附属医院老年科

出　　处：《中华中医药学刊》2019年第8期2013-2016,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：青海省科技厅攻关项目(2014-NS-120-1)

摘　　要：目的:研究丹红注射液联合曲克芦丁治疗急性脑梗死的疗效及对hs-CRP、TNF-α和IL-6影响。方法:120例急性脑梗死患者随机分为对照组和观察组,每组60例。对照组患者在常规对症治疗基础上给予曲克芦丁脑蛋白水解物注射液,治疗组患者在对照组患者基础上给予丹红注射液。比较两组患者临床疗效、hs-CRP、TNF-α和IL-6水平、凝血功能、NIHSS、BI评分和SF-36量表评分不良反应发生率。结果:对照组和治疗组患者治疗有效率分别为(83.33%)和(95.00%),治疗组疗效优于对照组,两组治疗有效率比较差异有统计学意义(P<0.05)。两组患者治疗后的hs-CRP、TNF-α和IL-6均显著改善(P<0.05);治疗后与对照组比较,治疗组的各项炎性因子水平改善更明显(P<0.05)。两组患者治疗后的纤维原蛋白、血小板计数、D-二聚体水平均显著改善(P<0.05);治疗后与对照组比较,治疗组的各项凝血功能指标水平改善更明显(P<0.05)。治疗后与对照组比较,两组患者治疗后的CSS、BI评分和SF-36量表评分均显著改善(P<0.05);治疗后与对照组比较,治疗组的各项CSS、BI评分和SF-36量表评分改善更明显(P<0.05)。对照组和治疗组患者不良反应总发生率分别为(10.00%)和(3.33%),治疗组显著低于对照组(P<0.05)。结论:采用丹红注射液联合曲克芦丁治疗急性脑梗死的临床疗效较好,能够改善患者hs-CRP、TNF-α和IL-6水平和患者凝血功能,并且改善患者神经功能、生活质量以及日常生活能力。Objective:To study the efficacy of Danhong Injection combined with tricloxine in the treatment of acute cerebral infarction and its effects on hs-crp, TNF-α and IL-6.Methods:A total of 120 patients with acute cerebral infarction were randomly divided into control group and observation group, with 60 patients in each group.Patients in the control group were treated with tricloxine hydrolysate injection on the basis of conventional symptomatic treatmentwhile those in the treatment group were treated with Danhong Injection on the basis of the control group.Clinical efficacy, hs-CRP, TNF-α and IL-6 levels, coagulation function, NIHSS, BI and SF-36 scales were compared between the two groups.Results:The effective rate of treatment was 83.33% in the control group and 95.00% in the treatment group, respectively. The therapeutic effect of the treatment group was better than that of the control group, and the difference between the two groups was statistically significant(P<0.05).After treatment, hs-CRP, TNF-α and IL-6 were significantly improved in both groups(P<0.05).After treatment, the levels of various inflammatory factors in the treatment group were significantly improved compared with those of the control group(P<0.05).The levels of fibrin, platelet count and d-dimer were significantly improved in both groups after treatment(P<0.05).After treatment, compared with the control group, the improvement of each coagulation function index was more obvious in the treatment group(P<0.05).After treatment, compared with the control group, the CSS, BI and SF-36 scale scores of the two groups were significantly improved(P<0.05).After treatment, compared with the control group, the improvement of various CSS, BI and SF-36 scales in the treatment group was more significant(P<0.05).The total incidences of adverse reactions in the control group and the treatment group were respectively 10.00% and 3.33%. The treatment group’s was significantly lower than that in the control group(P<0.05).Conclusion:Danhong Injection combined wi

关 键 词：胞二磷胆碱 普罗布考 急性脑梗死 临床观察 

分 类 号：R743.3[医药卫生—神经病学与精神病学]