左乙拉西坦单药治疗儿童癫痫86例疗效分析  

Analysis of the Efficacy of Levetiracetam as Monotherapy in 86 Children With Epilepsy

作　　者：于海丽 吕祖芳[1] 赵华锋[1] YU Haili;LV Zufang;ZHAO Huafeng(Department of Pediatrics,People’s Hospital of Weifang,Weifang Shandong 261041,China)

机构地区：[1]潍坊市人民医院儿科

出　　处：《中国卫生标准管理》2019年第15期71-74,共4页China Health Standard Management

摘　　要：目的观察左乙拉西坦(1evetiracetam,LEV)单药治疗儿童特发性癫痫的疗效、不良反应及对脑电图的影响。方法收集2017年1月-2018年9月于本院儿内科新确诊的86例癫痫患儿,给予左乙拉西坦单药治疗,用药期间观察患儿的癫痫发作情况及不良反应,用药前后进行血常规、血生化、脑电图等检查,6个月后进行疗效判定。结果癫痫发作控制率58.13%,总有效率为91.86%;脑电图缓解率占77.91%;加量期不良反应率为15.12%,维持期不良反应率为8.14%,且症状轻微。结论左乙拉西坦单药治疗儿童癫痫有良好疗效,不良反应较少,可选择作为儿童癫痫一线治疗的药物。Objective To observe the efficacy, adverse reactions and electroencephalogram(EEG) improvement of Levetiracetam(LEV)monotherapy in the children with idiopathic epilepsy. Methods 86 children with newly diagnosed epilepsy, collected from January 2017 to September2018 in the hospital, were treated with LEV monotherapy, following-up 6 months. Pre-treatment and treatment, all children are examined with routine blood test, blood biochemical and EEG. To evaluate clinical efficacy, EEG improvement, adverse reactions after 6 months. Results Control rate was58.13%, total effective rate was 91.86%;EEG remission rate was 77.91%;the incidence of adverse reactions was 15.12% during the increased doses,the incidence of adverse reactions was 8.14% during maintenance treatment,symptom were mild. Conclusion LEV monotherapy has favorable efficacy on controlling clinical onset and few adverse reactions, so it can be selected as the first-line treatment in children with epilepsy.

关 键 词：左乙拉西坦 癫痫 儿童 疗效 不良反应 脑电图 

分 类 号：R742[医药卫生—神经病学与精神病学]