铁死亡在肿瘤中的研究进展  

Advances in research on ferroptosis in tumors

作　　者：汪洋[1] 宋紫烨 徐梦菲 何灿 蔡红兵[1] WANG Yang;SONG Ziye;XU Mengfei;HE Can;CAI Hongbing(Department of Gynecological Oncology,Zhongnan Hospital of Wuhan University/HubeiCancer Clinical Study Center/Hubei Key Laboratory of Tumor Biological Behaviors,Wuhan,Hubei 430071,China)

机构地区：[1]武汉大学中南医院妇瘤科/湖北省肿瘤医学研究中心/肿瘤生物学行为湖北省重点实验室

出　　处：《重庆医学》2019年第15期2633-2636,共4页Chongqing medicine

基　　金：国家自然科学基金项目(81272866)

摘　　要：铁死亡是近年来发现的一种细胞死亡形式,主要以铁依赖的脂质活性氧(ROS)产生为特点,而脂质ROS的清除主要依赖于谷胱甘肽过氧化物酶4(GPX4),当脂质ROS产生和清除失平衡时,则会导致铁死亡的发生。肿瘤细胞可调节脂质ROS的生成和清除,以控制铁死亡过程。本文就铁死亡的机制及其与肿瘤的关系进行归纳总结,期望为靶向铁死亡治疗肿瘤提供理论依据。Ferroptosis is a form of cell death discovered in recent years,mainly characterized by the production of iron-dependent lipid reactive oxygen species(ROS),and lipid ROS clearance is mainly dependent on glutathione peroxidase 4(GPX4).When lipid ROS production and clearance are imbalance,which can lead to ferroptosis.Tumor cells control iron death processes through regulating lipid ROS production and clearance.This paper summarized the mechanism of ferroptosis and its relationship with tumors,so as to provide a theoretical basis for targeting ferroptosis to treat tumors.

关 键 词：铁死亡 铁 脂质 活性氧 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]