血清ANGPTL 2联合EGFR对乳腺癌患的诊断价值研究  

Diagnostic value of serum ANGPTL-2 combined with EGFR in patients with breast cancer

作　　者：屈睿 胡红心[1] 朱红胜[1] QU Rui;HU Hongxin;ZHU Hongsheng(Department of Clinical Laboratory,Suzhou Municipal Hospital,Suzhou,Jiangsu 215000,China)

机构地区：[1]苏州市立医院检验科

出　　处：《国际检验医学杂志》2019年第15期1868-1871,共4页International Journal of Laboratory Medicine

基　　金：苏州市科教兴卫青年科技项目(KJXW2016030)

摘　　要：目的检测表皮生长因子受体(EGFR)和血管生成素样蛋白-2(ANGPTL-2)水平在乳腺癌患者中的变化,探讨这两项指标在乳腺癌诊断中的价值及相关性,以期为乳腺癌的辅助诊断提供依据。方法将120例初诊乳腺癌患者(乳腺癌组),120例乳腺良性病变患者(良性组)和80例健康体检者(对照组)纳入本研究,收集患者的临床和病理资料,分析统计患者的临床病理特征。空腹采集静脉血进行血清EGFR和ANGPTL-2检测,比较各组间和各病理特征组间的水平差异,绘制ROC曲线分析血清EGFR和ANGPTL-2对乳腺癌的诊断价值,采用Pearson相关进行EGFR和ANGPTL-2间的相关性分析。结果乳腺癌组患者血清EGFR和ANGPTL-2水平明显高于良性组和对照组(P<0.05),良性组患者血清ANGPTL-2水平高于对照组(P<0.05);肿瘤直径≥5cm患者血清ANGPTL-2水平明显高于肿瘤直径<5cm患者(P<0.05),而EGFR水平无明显差异(P>0.05);血清EGFR和ANGPTL-2水平随着TNM分期的增加而呈升高趋势,组间比较差异有统计学意义(P<0.05);肿瘤有转移患者的血清EGFR和ANGPTL-2水平显著高于肿瘤无转移患者(P<0.05);ROC曲线分析得出血清EGFR、ANGPTL-2以及二者联合对乳腺癌的诊断曲线下面积(AUC)分别为0.841、0.897、0.936,敏感度分别为85.6%、80.2%、82.3%,特异度分别为62.5%、85.0%、90.2%;Pearson相关性分析显示,乳腺癌患者血清EGFR和ANGPTL-2水平呈正相关(r=0.52,P<0.001)。结论乳腺癌患者血清EGFR和ANGPTL-2水平升高,且二者间呈正相关,对乳腺癌具有较高的诊断价值。Objective To detect the changes of EGFR and ANPTL-2 concentrations in patients with breast cancer(BC),and to explore the diagnostic value and correlation analysis of each indicator in BC,so as to provide the basis for the auxiliary diagnosis of BC.Methods A total of 120 cases of newly diagnosed breast cancer(breast cancer group),120 cases of benign breast lesions(benign group)and 80 cases of health check-up(control group)were selected as the research objects.The clinical data of patients were collected and the clinical and pathological characteristics were analyzed.Fasting venous blood was collected for serum EGFR and ANPTL-2 measurement,and the changes between groups and pathological characteristics were compared.ROC curve was drawn to analyze the diagnostic value of serum EGFR and ANPTL-2 for BC.Pearson method was used to analyze the correlation between EGFR and ANPTL-2.Results The serum concentrations of EGFR and ANGPTL-2 in breast cancer group were significantly higher than those in benign group and control group,and the serum concentrations of ANGPTL-2 in benign group were higher than those in control group(P<0.05).The concentration of serum ANGPTL-2 in patients with tumor diameter>5 cm was significantly higher than that in patients with tumor diameter<5 cm(P<0.05),but there was no significant difference in EGFR concentration.Serum concentrations of EGFR and ANPTL-2 increased with the increase of TNM stage,and there was statistical significance between groups(P<0.05).The serum concentrations of EGFR and ANPTL-2 in patients with metastasis were significantly higher than those in patients without metastasis.ROC curve analysis showed that the diagnostic area under curve(AUC)of serum EGFR,ANGPTL-2 and their combination for BC were 0.841,0.897 and 0.936,with sensitivity 85.6%,80.2%and 82.3%,specificity 62.5%,85.0%and 90.2%,respectively.Pearson correlation analysis showed that serum EGFR and ANPTL-2 levels were positively correlated in BC patients(r=0.52,P<0.001).Conclusion Serum levels of EGFR and ANPTL-2 in BC p

关 键 词：EGFR ANGPTL-2 乳腺癌 

分 类 号：R446.61[医药卫生—诊断学]