Hedgehog信号传导通路及其生物学功能  

Hedgehog signaling pathway and its function in biology

作　　者：闵明 王婷婷 张继东 MIN Ming;WANG Ting-Ting;ZHANG Ji-Dong(Department of Immunology,Zunyi Medical University,Special Key Laboratory of Gene Detection & Therapy of Guizhou Province,Zunyi 563000,China)

机构地区：[1]遵义医科大学免疫学教研室贵州省基因检测与治疗特色重点实验室

出　　处：《中国免疫学杂志》2019年第15期1903-1906,1912,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金(31660338);贵州省科技计划项目[黔科合基础(2016)1167];贵州省普通高等学校科技拔尖人才支持计划[黔教合KY字(2016)079];遵义医学院博士科研启动项目(F-739);贵州省留学人员科技创新项目[(2016)20];遵义医科大学研究生创新计划(ZYK014)

摘　　要：从胚胎到成体的发育过程中,Wnt、TGF-β、Notch、Hedgehog(Hh)这4条信号通路是主要的信号调节通路。他们调控着胚胎早期发育、细胞的增殖分化以及维持机体的稳态。其中Hh信号传导通路在多种生理调控中起着关键的作用。Hh信号通路不仅参与细胞生长、分化,组织器官的发生和形成,在组织器官的损伤修复、免疫调节方面也发挥着重要作用。但是Hh信号通路异常激活也会引起发育异常甚至引发肿瘤。Four well-known signal transduction pathways,Wnt,TGF-β,Notch and Hedgehog(Hh) play a vital role in diverse biological processes,such as embryonic development,cell proliferation,differentiation and homeostasis.Among them,Hh signaling is an indispensable part in physiological regulation.Not only does the Hh signaling participate in cell growth,differentiation and morphogenesis of organs,but also exerts great influence in immune regulation and regeneration after injury.However,disorder of Hh signaling pathway may lead to abnormal development and tumor.

关 键 词：HEDGEHOG GLI 生物学功能 初级纤毛 

分 类 号：R392.9[医药卫生—免疫学]