纳米碳在子宫内膜癌前哨淋巴结检测中的应用  

The clinical study of sentinel lymph node mapping by using carbon nanoparticle for endometrial cancer

作　　者：黄康榕 王金凤 王月玲[1] 李琛[1] 冀静[1] Huang Kangrong;Wang Jinfeng;Wang Yueling;Li Chen;Ji Jing(Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061, China)

机构地区：[1]西安交通大学第一附属医院妇产科

出　　处：《现代肿瘤医学》2019年第17期3090-3092,共3页Journal of Modern Oncology

基　　金：陕西省自然基金重点研发计划一般项目(编号:2017SF-015);西安交通大学第一附属医院院级新医疗新技术项目(编号:XJYFY-2016W8)

摘　　要：目的:探讨纳米碳在子宫内膜癌前哨淋巴结检测中的可行性及应用价值。方法:选择25例经手术治疗的子宫内膜癌患者,术中于子宫前壁、后壁、宫底两侧共4点处注射纳米碳混悬液,识别黑染的淋巴结,并记录前哨淋巴结相关信息,淋巴结分开单独送病理检查行HE染色。结果:25例子宫内膜癌患者均出现子宫浆膜面黑染,前哨淋巴结检出率为84%(21/25),共计114枚,其中盆腔双侧检出率为81%,盆腔一侧检出率为19%。3例患者发生淋巴结转移,均为SLN转移。结论:纳米碳作子宫内膜癌前哨淋巴结的示踪剂具有可行性,对于子宫内膜癌淋巴结转移判断有一定的临床应用价值。Objective:To analyze the feasibility and value of detecting sentinel lymph node(SLN) in endometrial carcinoma by using carbon nanoparticle.Methods:25 cases of endometrial carcinoma who had accepted surgical treatment were enrolled.The carbon nanoparticle was injected into 4 sites of uterus including midpoint of anterior wall,bilateral fundus and midpoint of posterior wall.the black-stained lymph nodes were identified and recorded.All sentinel lymph nodes were histopathologically examined by HE stain.Results:Uterine serosa were found to be black-stained in all 25 patients.The SLN detection rate was 84%(21/25).The total number of SLN was 114.Bilateral pelvic detection rate was 81% and unilateral pelvic dectiont rate was 19%.Lymphatic metastasis was found in 3 cases.All of them were SLN metastasis. Conclusion:Using carbon nanoparticles for sentinel lymph node mapping in endometrial cancer is feasible and effective.It is useful for estimating lymphatic metastasis of endometrial cancer.

关 键 词：纳米碳 前哨淋巴结 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]