子宫内膜癌微环境中间质细胞相关信号通路的研究进展  

Progress on Stromal Cell-related Signaling Pathways in Endometrial Carcinoma Microenvironment

作　　者：伍健[1] 张虹[2] 陶祥[3] WU Jian;ZHANG Hong;TAO Xiang(Department of Pathology, Gongli Hospital, The Second Military Medical University, Shanghai 200135, China;Department of Pharmacy, Tongji Hospital, Tongji University, Shanghai 200065, China;Department of Pathology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China)

机构地区：[1]第二军医大学附属公利医院病理科,上海200135 [2]同济大学附属同济医院药剂科,上海200065 [3]复旦大学附属红房子医院病理科,上海200011

出　　处：《肿瘤防治研究》2019年第8期733-736,共4页Cancer Research on Prevention and Treatment

基　　金：浦东新区卫计委薄弱学科群建设基金（PWZbr2017-21）;国家自然科学基金青年项目（81402151）

摘　　要：和子宫内膜癌上皮细胞相似,肿瘤微环境中主要细胞的间质细胞也表达雌激素受体(ER),同样也受到雌激素的调控。在雌激素和抑癌基因的作用下,间质细胞与肿瘤细胞的增殖、侵袭和转移等密切相关。间质细胞相关信号通路的研究,为探索雌、孕激素失衡的发病机制、肿瘤复发和化疗耐药等机制提供新的依据。Similar to epithelial cells of endometrial carcinoma, stromal cells, as the major cells in tumor microenvironment, also express estrogen receptor(ER) and are regulated by estrogen. In the roles of estrogen and tumor suppressor genes, stromal cells are closely related to the proliferation, invasion and metastasis of tumor cells. The study of the signal pathways in stromal cells provides new evidence to explore the pathogenesis of estrogen and progesterone imbalance, tumor recurrence, chemotherapy resistance and so on.

关 键 词：间质细胞 信号通路 子宫内膜癌 微环境 雌激素 

分 类 号：R737[医药卫生—肿瘤]