帕金森综合征患者非运动症状发生特点、影响因素及对生活质量的影响  

Characteristics and influencing factors of non-motor symptoms in patients with Parkinson′s disease and its effects on quality of life

作　　者：张建勋[1] 高秀先[1] 万和斌[1] 徐达青[1] 邹玉凤 聂益军[2] ZHANG Jian -xun;GAO Xiu-xian;WAN He-bin;XU Da-qing;ZOU Yu -feng;NIE Yi-jun(Department of Neurology, Jiujiang First People rs Hospital, Jiujiang 332000, Jiangxi, China)

机构地区：[1]九江市第一人民医院神经内科,江西九江332000 [2]南昌大学第一附属医院神经内科,江西南昌330006

出　　处：《广东医学》2019年第15期2179-2183,共5页Guangdong Medical Journal

基　　金：江西省卫生计生委科技计划项目(编号:20185096)

摘　　要：目的探讨帕金森病(Parkinson disease,PD)患者非运动症状(non motor symptoms,NMS)发生的特点、影响因素及对生活质量的影响。方法选取原发性PD患者50例作为观察组,选取同期身体健康、无神经系统疾病的体检者作为对照组,利用NMS量表分析PD患者临床症状,PD患者出现NMS的影响因素;同时由专业专科医生利用健康调查简表(SF-36)分析影响PD患者生活质量的因素以及汉密尔顿焦虑(HAMA)量表、汉密尔顿抑郁(HAMD)量表、阿尔茨海默病评定量表认知部分、匹兹堡睡眠指数(PSQI)以及日常生活能力(ADL)量表评价比较对照组与观察组的PD患者焦虑、抑郁、记忆、睡眠以及日常生活能力。结果 PD患者NMS合并出现,33例PD患者至少出现一项以上NMS(66%),睡眠障碍、便秘、多汗、抑郁是发生率较高的临床症状;PD患者出现NMS与PD患者病程、临床类型以及病情分级相关(P<0.05),与年龄、性别、职业及文化程度无关(P>0.05);观察组PD患者生活质量评分低于对照组(P<0.05),而HAMA、HAMD、PSQI、ADL以及阿尔茨海默病评定量表-认知部分评分均高于对照组(P<0.05)。结论 PD患者NMS发生率极高,严重影响患者的生活质量,早期进行评价和干预NMS对于提高PD患者的生存率具有重要意义。Objective To investigate the characteristics and influencing factors of a non - motor symptoms (NMS) in Parkinson's disease ( PD) patients and its effects on quality of life. Methods From June 2016 to June 2018 , 50 patients with primary PD were selected as observation group, and those who were healthy and without nerve system diseases were selected as control group. The clinical symptoms of PD patients with NMS scale and influencing factors of NMS in PD patients were analyzed. At the same time, the factors influencing the quality of life of PD patients were analyzed by using the health survey summary table (SF-36), and the cognitive part of Hamilton anxiety ( HAMA) scale, Hamilton depression ( HAMD) scale, and Alzheimer's disease rating scale. The Pittsburgh Sleep Index (PSQI) and activity of Daily living ( ADL) were used to determine the anxiety, depression, memory, sleep and ADL. Results There was at least one item of NMS in 33 patients with PD (66%). Sleep disorder, constipation, sweating and depression were the clinical symptoms with high incidence. And the incidence of NMS in patients with PD was correlated with the course, clinical type and grade of PD ( P < 0. 05 ), but not with age, sex or occupation and education ( P > 0. 05 ). The quality of life in the study group was significantly lower than that of control group ( P < 0. 05 ), while the scores of HAMA, HAMD, PSQI, ADL and Alzheimer's disease rating scale - cognitive part significantly were higher than those of the control group ( P < 0. 05). Conclusion The incidence of NMS in patients with PD is very high, which seriously affects the quality of life of patients. Early evaluation and intervention of NMS is of great significance in improving the survival of PD patients.

关 键 词：帕金森病 非运动症状 临床特征 影响因素 生活质量 

分 类 号：R741.04[医药卫生—神经病学与精神病学] R741.041[医药卫生—临床医学]