海洋来源的荧光天然产物  

Marine fluorescent natural products

作　　者：朱丹阳[1,2] 姜永贺 蒋宏飞 于日磊 江涛[1,2] ZHU Dan-yang;JIANG Yong-he;JIANG Hong-fei;YU Ri-lei;JIANG Tao(Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy, Ocean University of China,Qingdao 266003,China;Laboratory for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology,Qingdao 266237,China)

机构地区：[1]中国海洋大学海洋药物教育部重点实验室,医药学院,山东青岛266003 [2]青岛海洋科学与技术试点国家实验室海洋药物与生物制品功能实验室,山东青岛266237

出　　处：《中国海洋药物》2019年第4期58-64,共7页Chinese Journal of Marine Drugs

基　　金：“蓝色药库”技术创新工程,山东省重大科技创新专项(2018SDKJ0403-2);青岛海洋科学与技术国家实验室鳌山科技创新计划项目(2015ASKJ02)资助

摘　　要：近年来海洋天然产物越来越引起科学家们的关注。由于在珊瑚礁珊瑚和海葵等海洋无脊椎动物中具有荧光现象普遍,许多海洋天然产物除了药用和生物学价值外,还具有突出的荧光特性。本文从来源、发色团结构以及应用等方面进行综述,介绍了Ageladine A、Marmycin A、两种新型羟基蒽醌和Zoanthoxanthins等几种海洋来源的荧光小分子,以及代表性的海洋荧光蛋白GFP家族和藻胆蛋白。它们具有独特的光学性质将在生物医学领域广泛应用。Marine natural products have increasingly captured the attention of researchers in the past few decades.In addition to the medicinal and biological values,many marine natural products also have outstanding fluorescent properties.Fluorescence is very common in marine invertebrates such as corals and sea anemones.This review summarized several marine-derived fluorescent molecules including ageladine A,marmycin A,zoanthoxanthins and the representative marine fluorescent proteins,GFP family and phycobiliproteins.They have unique optical properties and are widely used in biomedicine.

关 键 词：海洋荧光天然产物 海洋荧光小分子 海洋荧光蛋白 

分 类 号：R914[医药卫生—药物化学]