Relationship between Atrial Tissue Remodeling and ECG Features in Atrial Fibrillation  

作　　者：Li-ya RAO Yi MAO Kun HUANG Yu-shu LI Yan-wen SHU 

机构地区：[1]Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China

出　　处：《Current Medical Science》2019年第4期541-545,共5页当代医学科学（英文）

摘　　要：The difference in the atrial organizational structure between patients with atrial fibrillation (AF) and those with sinus rhythm was investigated.In order to analyze the rationality in explaining the electrocardiogram (ECG) characteristics of AF with statistics data or tissue remodeling model,and the logical relationship between the hypothesis of pulmonary veins (PV) muscle sleeves and that of multi wavelets in mechanism of AF,we examined the expression of collagen volume fraction of type I (CVF-I ) with picrosirius red staining,connexin 40 (Cx40) by immunohistochemistry,and intercalated disc (ID) using transmission electron microscope in atrial tissue.The results showed that there was significant difference in the expression of CVF-I (t=3.827,P<0.01),Cx40 (t=4.21,P<0.01),and groups of the ID that keeping the electrical transmission and atrial electrical coupling synchronization (t=15.116,P<0.001),but no significant difference was found in total IDs (t=0.611,P=0.543) between patients with AF and those with sinus rhythm.The quantitative differences in the tissue remodeling could not explain the ECG characteristics of AF.The number of normal IDs and abnormal distribution are the structural basis to trigger and maintain atrial electrical remodeling,and induce and maintain AF.Such histological reconstruction supports the hypothesis of multi wavelets and can also explain ECG features.

关 键 词：ATRIAL FIBRILLATION collagen volume fraction of type Ⅰ CX40 INTERCALATED disc ELECTROCARDIOGRAM 

分 类 号：R[医药卫生]