Enantioselective Addition of Allyltrichlorosilane to Bulky-substituted Aldehydes Catalyzed by Axial N,N'-Dioxide Pivalate  

作　　者：WANG Jie WU Shijie WANG Xiaoke LI Longfei YANG Kan ZHU Huajie LI Wan LIU Li 

机构地区：[1]College M Pharmacy,Hebei University, Baoding 071002,P. R.China [2]College of Medicine,Hebei University,Baoding 071002,P. R.China [3]College of Chemistty,Hebei University,Baoding 071002,P.R.China

出　　处：《Chemical Research in Chinese Universities》2019年第4期604-608,共5页高等学校化学研究（英文版）

摘　　要：Allylation of bulky-substituted aromatic aldehydes with allyltrichlorosilanes were catalyzed by axial biscarboline N.N-dioxide esters with high enaiitioselectivities up to 92% e.e. for l-(4-chlorophenyl)-9-methyl-9Hpyrido[3,4-b]indole-3-carbaldehyde and 90% e.e.for 1-(3-methoxyphenyl)-9-methyl-9H-pyrido[3,4-b]indole-3-carbaldehyde, respectively.Total 22 aldehydes were tested with good yields and enantioselectivities.Catalyst 4f exhibited good catalytic enantioselectivity.

关 键 词：Enantioselective ALLYLATION Biscarboline N N'-dioxide pivalate DRIVING-FORCE Catalytic space 

分 类 号：O6[理学—化学]