微小RNA-7在脑部的表达调控机制和对生理功能的影响  

The expression regulation mechanism of microRNA-7 and its influence on physiological function in the brain

作　　者：赵娟娟 岳东旭 郭萌萌[2,3] 陈静 唐琳[2,3] 徐林 ZHAO Juan-Juan;YUE Dong-Xu;GUO Meng-Meng;CHEN Jing;TANG Lin;XU Lin(School of Medicine,Guizhou University,Guiyang 550025,China;Guizhou Key Laboratory of Gene Detection and Treatment,Zunyi 563000,China;Department of Immunology,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]贵州大学医学院,贵阳550025 [2]贵州省基因检测与治疗特色重点实验室,遵义563000 [3]遵义医学院免疫学教研室,遵义563000

出　　处：《生命科学》2019年第7期699-704,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31370918);贵州省高层次创新型人才项目(黔科合人才(2016)4031号);遵义医学院优秀青年人才计划(15ZY-001);遵义市科技局遵义医学院2016年科学技术联合资金项目(遵市科合社字(2016)38号);2016年硕士科研启动基金(F-825);贵州省研究生科研基金立项课题(KYJJ2017002)

摘　　要：微小RNA-7(microRNA-7, miR-7)作为微小RNA家族成员之一,在机体脑部组织中高表达。研究发现,miR-7与机体脑部组织的发育、功能维持和病理进程密切相关,提示其可能是一个对脑部生理、病理发生过程具有重要作用的新调节分子。该文综述了近年来关于miR-7在脑部生理发育和功能中的研究进展,以期为阐明以miR-7为代表的微小RNA分子在脑部发育和生理功能发展过程中的作用机制,以及为脑部相关临床疾病的诊断、治疗新策略的开发提供帮助。MicroRNA-7(miR-7), one of the members of microRNA(miRNA) family, is highly expressed in the brain tissue. Studies have shown that miR-7 is closely related to the physiological development, functional maintenance and pathological process of brain tissue, which suggesting that miR-7 may be a new regulatory molecule that plays an important role in the physiological and pathological process of brain. In this paper, we summarize the research progress on the role of miR-7 in the physiological function and development of brain in recent years, in order to provide help for the elucidation of mechanism of miR-7, a representative member of miRNAs molecules, in the physiological function and development of brain, as well as the development of relatedbrain diseases with new clinical diagnosis and treatment strategies.

关 键 词：微小RNA-7 脑部组织 表达 生理功能 调控 

分 类 号：Q522[生物学—生物化学] R74[医药卫生—神经病学与精神病学]