GerdQ量表对胃食管反流性疾病诊断价值的Meta分析  

The diagnostic value of GERDQ questionnaire for GERD: a meta-analysis

作　　者：黎丽群 谢胜[2] 陈明冰 李建锋 谭金晶[2] LI Liqun;XIE Sheng;CHEN Mingbing;LI Jianfeng;TAN Jinjing(Guangxi University of Traditional Chinese Medicine,Nanning 530000,P.R.China;Department of Spleen and Stomach,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530000,P.R.China)

机构地区：[1]广西中医药大学,南宁530000 [2]广西中医药大学第一附属医院脾胃科,南宁530000

出　　处：《中国循证医学杂志》2019年第8期915-923,共9页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金项目(编号：81460723)

摘　　要：目的系统评价GerdQ量表对胃食管反流性疾病的诊断价值。方法计算机检索PubMed、Webof Science、EBMR、CNKI、CBM、VIP和WanFang Data数据库,搜集有关GerdQ量表诊断胃食管反流性疾病的诊断性研究,检索时限从建库至2018年1月1日。由2位研究者独立筛选文献、提取资料,并评价纳入研究的偏倚风险后,采用Meta-Disc 1.4软件进行Meta分析,采用Stata 12.0软件绘制漏斗图并评估发表偏倚。结果共纳入20个研究,包含7 978例患者,确诊的胃食管反流性疾病患者共4 848例。Meta分析结果显示:①GerdQ量表诊断胃食管反流性疾病的合并Sen、Spe、+LR、-LR、DOR分别为:0.79[95%CI(0.78,0.81)]、0.66[95%CI(0.65,0.68)]、2.28[95%CI(1.77,2.94)]、0.37[95%CI(0.27,0.52)]、6.34[95%CI(3.59,11.19)];SROC(AUC)为0.789 3,Q*指数为0.726 6。②当临界值为7分时,GerdQ诊断GERD的准确性最高,9分次之。③中国人群使用GerdQ量表诊断胃食管反流性疾病的准确性更高。结论GerdQ量表诊断胃食管反流性疾病的准确性较高,可作为诊断胃食管反流性疾病的辅助工具,值得临床推广使用。受纳入研究数量和质量限制,上述结论尚需开展更多高质量研究予以验证。Objectives To systematically review the diagnostic value of GerdQ questionnaire for diagnosing the gastro-oesophageal reflux disease(GERD).Methods PubMed,Web of Science,EBMR,CNKI,CBM,VIP and WanFang Data databases were searched to collect studies on the diagnostic value the GerdQ questionnaire in diagnosing the GERD from inception to January 1st 2018.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies.Then meta-analysis was performed by using Meta-Disc 1.4 software.We used the Stata 12.0 software to assess the publication bias with funnel plots.Results A total of 20 studies were enrolled,including 7 978 patients.Among them,4 848 patients were confirmed with GERD.The results of meta-analysis showed that:a)The pooled sensitivity,specificity,+LR,-LR,and DOR were 0.79(95%CI 0.78 to 0.81),0.66(95%CI 0.65 to 0.68),2.28(95%CI 1.77 to 2.94),0.37(95%CI 0.27 to 0.52)and 6.34(95%CI 3.59,11.19),SROC(AUC)was 0.789 3,and Q*was 0.726 6.b)When the cut-off was 7,the diagnostic accuracy of GerdQ questionnaire for the GERD was the highest,and that of 9 was the second.c)The diagnostic accuracy of GerdQ questionnaire was higher when it was used in China.Conclusions GerdQ questionnaire has a moderate accuracy for the diagnosis of GERD,which can be a useful complementary tool for diagnosing GERD,and can be popularized in clinical settings.Due to limitation of quantity and quality of included studies,the above conclusions requires verification by more high quality studies.

关 键 词：GerdQ量表 胃食管反流性疾病 META分析 诊断价值 

分 类 号：R571[医药卫生—消化系统]