中、美、欧、日4种药典人参含量测定方法比较  

Comparison of determination methods of Ginseng in Chinese Pharmacopoeia, American Pharmacopoeia, European Pharmacopoeia and Japanese Pharmacopoeia

作　　者：曹丽娟 姜恒丽 张旭 屈文佳 耿晓康 李向日[2] Cao lijuan;Jiang hengli;Zhang xu;Qu wenjia;Geng xiaokang;Li xiangri(China Medico Corporation, Tianjin key laboratory of TCM decoction processing technology enterprise, Tianjin 300301;Beijing University of Traditional Chinese Medicine, Beijing 102488)

机构地区：[1]盛实百草药业有限公司,天津市中药饮片炮制技术企业重点实验室,天津300301 [2]北京中医药大学中药学院,北京102488

出　　处：《天津药学》2019年第4期19-23,共5页Tianjin Pharmacy

基　　金：国家中药标准化项目(No.ZYBZH-Y-TJ-043)

摘　　要：目的:对《中国药典》(2015年版)、《美国药典》(第40版)、《欧洲药典》(9.0版本)、《日本药局方》(第17版)中人参含量检测方法进行分析比较,通过试验考查不同前处理方法及检测方法对人参皂苷类活性成分的影响,为人参质量标准的修订提供参考。方法:分别按照4种药典的前处理方法及含量检测分析方法对人参样品进行含量检测,并比较分析其对测定结果的影响。结果:人参含量检测过程中,前处理方法各有优势,《中国药典》方法除杂效果好,《美国药典》方法最为环保,《日本药局方》成本最低,且人参皂苷Rg1、Rb1的提取率高。结论:前处理方法对人参含量检测影响作用显著,分析4国药典中供试品制备方法可为人参标准修订提供重要参考。Objective: We analyzed and compared the content determination of ginseng in Chinese Pharmacopoeia (2015 edition), United States Pharmacopoeia (40 th edition), European Pharmacopoeia (version 9.0) and Japanese Pharmacopoeia ( 17 th edition).The effects of different pretreatment methods and detection methods on ginsenosides were investigated in order to provide reference for the revision of ginseng quality standards. Methods: The influence of pretreatment methods and analysis methods on ginseng according to four Pharmacopoeias were compared and analyzed. Results: In the process of ginseng content detection, each method had its own advantages. In short, the impurity removal effect of Chinese Pharmacopoeia method was better. The method of United States Pharmacopoeia was the most environmentally friendly. The method of Japanese Pharmacopoeia had not only the lowest detection cost but also the higher extraction rate of Ginsenoside Rg 1 and Rb 1.Conclusion: The pretreatment methods had significant effects on the content determination of ginseng . This could provide important references for the revision of ginseng standards.

关 键 词：人参 含量测定 中国药典 美国药典 欧洲药典 日本药局方 

分 类 号：R927.2[医药卫生—药学]