经导管肝动脉栓塞与肝动脉灌注化疗栓塞在原发性肝癌介入治疗中的疗效比较  

Comparison on efficacy of transcatheter hepatic artery embolization and hepatic artery infusion chemoembolization in interventional treatment of primary hepatocellular carcinoma

作　　者：谢元明[1] XIE Yuan-ming(Department of Internal Medicine-Oncology,Sichuan Forestry Central Hospital,Chengdu 610081,China)

机构地区：[1]四川省林业中心医院肿瘤内科

出　　处：《中国实用医药》2019年第24期6-8,共3页China Practical Medicine

摘　　要：目的比较经导管肝动脉栓塞和肝动脉灌注化疗栓塞在原发性肝癌患者介入治疗中的临床疗效。方法60例原发性肝癌患者,根据患者入院日期单双号分为对照组和试验组,各30例。试验组予以肝动脉灌注化疗栓塞治疗,对照组予以经导管肝动脉栓塞治疗。比较两组近期治疗效果、疾病控制效果、不良反应发生情况及不同Child-Pugh分级患者1、2、3年生存情况。结果对照组近期有效率和疾病控制率分别为43.33%、56.67%,试验组近期有效率和疾病控制率分别为70.00%、83.33%;试验组近期有效率和疾病控制率均高于对照组,差异有统计学意义(P<0.05)。两组Child-Pugh分级A级和B级患者1、2、3年生存率比较差异均无统计学意义(P>0.05);试验组Child-Pugh分级C级患者1、2、3年生存率均高于对照组,差异有统计学意义(P<0.05)。试验组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论对原发性肝癌患者开展肝动脉灌注化疗栓塞治疗的效果优于经导管肝动脉栓塞治疗。Objective To compare the clinical efficacy of transcatheter hepatic artery embolization and hepatic artery infusion chemoembolization in interventional treatment of primary hepatocellular carcinoma. Methods A total of 60 primary hepatocellular carcinoma patients were divided into control group and experimental group according to the date of admission,with 30 cases in each group.The experimental group was treated with hepatic artery infusion chemoembolization,and the control group was treated with transcatheter hepatic artery embolization.Comparison was made on short-term therapeutic effect,disease control effect, occurrence of adverse reactions and 1,2 and 3-year survival of patients with different Child-Pugh grades between the two groups.Results The control group had short-term effective rate and disease control rate as 70.00% and 83.33%,and the control group had short-term effective rate and disease control rate as 43.33% and 56.67%. The experimental group had higher short-term effective rate and disease control rate than the control group,and the difference was statistically significant (P<0.05).There was no statistically significant difference in 1,2 and 3-year survival rate of patients with Child-Pugh grade A and B in two groups (P>0.05).The experimental group had higher 1,2 and 3-year survival rate of patients with Child-Pugh grade C than the control group,and the difference was statistically significant (P<0.05).The experimental group had statistically significant difference in incidence of adverse reactions,compared with the control group (P>0.05).Conclusion Hepatic artery infusion chemoembolization shows better effect for patients with primary hepatocellular carcinoma than transcatheter hepatic artery embolization.

关 键 词：经导管肝动脉栓塞 肝动脉灌注化疗栓塞 原发性肝癌 介入治疗 

分 类 号：R735.7[医药卫生—肿瘤]