经肝动脉化疗栓塞联合经皮射频消融术治疗原发性肝癌的疗效观察  

Therapeutic effect of transcatheter arterial chemoembolization combined with percutaneous radiofrequency ablation for primary hepatic carcinoma

作　　者：李曦[1] 林瑶[1] 刘源[1] 曹贞 LI Xi;LIN Yao;LIU Yuan;CAO Zhen(Department of Vascular Surgery,Teaching Hospital of Chengdu University of T.C.M,Chengdu 610072,China)

机构地区：[1]成都中医药大学附属医院血管外科

出　　处：《西部医学》2019年第9期1403-1406,共4页Medical Journal of West China

摘　　要：目的探讨经肝动脉化疗栓塞(TACE)联合经皮射频消融术(PRFA)与单独应用经皮射频消融术治疗原发性肝癌的临床疗效。方法选择2012年3月~2014年3月在我院诊治的肝癌患者90例,随机分为观察组(50例)与对照组(40例)。观察组予以经肝动脉化疗栓塞联合经皮射频消融术,对照组应用经皮射频消融术治疗,观察两组疗效及预后情况。结果术后1个月两组患者并发症如疼痛、肺部感染、出血、恶心呕吐等发生率差异无统计学意义(P>0.05);两组术后1个月时血清丙氨酸氨基转移酶(ALT)与门冬氨酸氨基转移酶(AST)水平均低于术前(P<0.05),但观察组术后一个月血清ALT和AST值显著低于对照组(P<0.05);观察组与对照组比较能明显提高近期有效率(P<0.05)。结论两种治疗方案均能有效治疗原发性肝癌,但经肝动脉化疗栓塞联合经皮射融术相对于单独应用经皮射频消融术,在原发性肝癌治疗中具有更高的缓解率,更有利于肝功能的恢复,可减少术后并发症。Objective To compare the clinical efficacy of transcatheter arterial chemoembolization combined with percutaneous radiofrequency ablation and percutaneous radiofrequency ablation alone in the treatment of primary hepatic carcinoma.Methods 90 patients with hepatocellular carcinoma were selected for this study.According to the different treatment methods,the patients were divided into transcatheter arterial chemoembolization combined with percutaneous radiofrequency ablation group (50 cases),and percutaneous radiofrequency ablation alone group (40 cases),and the outcome was observed.Results There was no significant difference in the incidence of complications such as pain,lung infection,bleeding,and nausea and vomiting at 1 month after surgery.The levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) at 1 month after surgery in both groups were lower than those before surgery ( P <0.05),but serum ALT and AST in the combined treatment group were significantly lower than those treated with radiofrequency ablation alone ( P <0.05).At the same time,the combined treatment group also significantly improved the recent effective rate compared with the percutaneous radiofrequency ablation treatment alone group ( P <0.05).Conclusion Both treatment options can effectively treat primary liver cancer,but compared with radiofrequency ablation alone,transcatheter arterial chemoembolization combined with percutaneous radiofrequency ablation has a higher remission rate in the treatment of primary liver cancer.More conducive to the recovery of liver function and reduce postoperative complications.

关 键 词：原发性肝癌 肝动脉化疗栓塞 射频消融 联合治疗 

分 类 号：R735.7[医药卫生—肿瘤]