美罗培南联用丙戊酸钠致癫痫的病案分析  

Analysis of epilepsy caused by meropenem combined with sodium valproate

作　　者：李祚勇[1] 郭春钰[1] LI Zuo-yong;GUO Chun-yu(The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000)

机构地区：[1]赣南医学院第一附属医院

出　　处：《赣南医学院学报》2019年第8期815-817,819,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:让临床医师、药师进一步认识药物间的相互作用,了解其发生机制及处理方法,提高临床诊疗水平。方法:通过分析临床药师参与继发癫痫合并肺部感染患者,经美罗培南和丙戊酸钠(VPA)联合治疗后出现癫痫大发作,进行用药分析排查。结果:美罗培南能使VPA在体内的血药浓度显著降低,诱发癫痫发作。结论:在临床治疗中,应避免两药联用,若确需联用,应监测VPA血药浓度,以便及时调整剂量。Objective: To make clinicians and pharmacists further understand the interaction between drugs, understand its mechanism and treatment methods, and improve the level of clinical diagnosis and treatment. Methods: By analyzing the clinical pharmacists involved in the secondary epilepsy patients with pulmonary infection, after meropenem and sodium valproate combined treatment, epilepsy grand seizure occurred, drug analysis was conducted. Results: Meropenem significantly reduced the blood concentration of VPA in vivo and induce epileptic seizures. Conclusions: In clinical treatment, meropenem should be avoided in combination with VPA. If it is necessary, the blood concentration of VPA should be monitored in order to adjust the dosage in time.

关 键 词：美罗培南 丙戊酸钠 血药浓度 

分 类 号：R742.1[医药卫生—神经病学与精神病学]