双相障碍患者肠道菌群相对丰度与临床症状及认知功能的相关性  

Correlationof the relative abundance of gut microbiome with cognitive function and clinical symptoms in bipolar disorder

作　　者：贾敏[1] 王崴[1] 纪翠 董倩[1] 马青艳[1] 冯俊芹 范雅娟 朱峰[1] 马现仓[1] 高成阁[1] JIA Min;WANG Wei;JI Cui;DONG Qian;MA Qing-yan;FENG Jun-qin;FAN Ya-juan;ZHU Feng;MA Xian-cang;GAO Cheng-ge(Department of Psychiatry, The First Affiliated of Xi'an Jiaotong University, Xi'an 710061;Xi'an Jiaotong University Health Science Center, Xi'an 710061, China)

机构地区：[1]西安交通大学第一附属医院精神心理卫生科,陕西西安710061 [2]西安交通大学医学部,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2019年第5期778-783,793,共7页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省创新人才推进计划-重点科技创新团队计划(No.2017KCT-20);陕西省社会发展科技攻关项目(No.2016SF-150)~~

摘　　要：目的研究双相障碍患者肠道菌群的相对丰度与临床症状及认知功能之间的相关性。方法共纳入双相障碍患者27例(病例组),其中躁狂发作相17例(躁狂组),抑郁发作相10例(抑郁组);健康对照组23例(对照组)。使用MATRICS共识认知成套测验(MCCB)评估各组间的认知功能,应用16SrRNA测序技术获得组间肠道菌群多样性,分析肠道菌群相对丰度与临床症状及认知功能的相关性。结果①认知功能:病例组和躁狂组在符号编码及迷宫测验上的得分均较对照组降低(P<0.05);病例组在霍普金斯词语学习上的得分较对照组降低(P<0.05);抑郁组在霍普金斯词语学习上的得分较对照组(P<0.01)和躁狂组(P<0.05)降低。②肠道菌群相对丰度与临床症状及认知功能的相关性:拟杆菌属-普通拟杆菌种的相对丰度与年龄呈正相关(r=0.40,P<0.01);双歧杆菌种的相对丰度与杨氏躁狂量表(YMRS)总分呈负相关(r=-0.53,P<0.05);双歧杆菌属的相对丰度与蒙哥马利抑郁量表(MADRS)总分(r=-0.70,P<0.05)及心境恶劣因子分(r=-0.64,P<0.05)呈负相关,志贺菌属的相对丰度与MADRS的抑制因子分呈负相关(r=-0.66,P<0.05);大肠埃希氏菌菌种的相对丰度与MADRS抑制因子分呈负相关(r=-0.66,P<0.05)。躁狂组双歧杆菌种的相对丰度与认知功能呈负相关(P<0.05)。抑郁组双歧杆菌种、大肠埃希氏菌种及志贺菌属的相对丰度与认知功能相关呈负相关(P<0.05)。结论双相障碍急性发作期患者存在认知功能损害及肠道菌群多样性变化,菌群相对丰度的变化与疾病的严重程度及认知功能相关。Objective To study the correlation of the relative abundance of gut microbiome with cognitive function and clinical symptoms in bipolar disorder (BD).Methods We recruited 23 healthy controls (control group) and 27 BD patients (BD group), the latter of which consisted of 17 patients with manic episode (BDM group) and 10 patients with depressive episode (BDD group).We used MCCB to compare the cognitive function and used 16S rRNA sequencing technology to obtain gut microbiome diversity among the groups.We analyzed the correlation of the relative abundance of gut microbiome with cognitive function and clinical symptoms in BD.Results ① Cognitive function:The scores of symbol encoding and maze of BD group and BDM group were significantly lower than that of HC group ( P <0.05).The score of Hopkins Verbal Learning Test of BD group was significantly lower than that of HC group ( P <0.05).The score of Hopkins Verbal Learning Test of BDD group was significantly lower than that of HC group ( P <0.01) and BDM group ( P <0.05).② Correlation of the relative abundance of gut microbiome with cognitive function and clinical symptoms:The relative abundance of Bacteroides_plebeius was significantly positively related to age ( r =0.40, P <0.01), and that of Bifidobacterium_adolescentis was significantly negatively related to the total score of YMRS (r=-0.53, P <0.05).The relative abundance of Bifidobacterium was significantly negatively related to the total score of MADRS ( r =-0.70, P <0.05) and the score of dysphoria factor ( r =-0.64, P <0.05).The relative abundance of Escherichia-Shigella was significantly negatively related to the score of retardation factor ( r =-0.66, P <0.05).That of Eschericha_coli was significantly negatively related to the score of retardation factor ( r =-0.66, P <0.05).The relative abundance of adolescentis in BDM group was significantly negatively related to cognitive function ( P <0.05).The relative abundance of adolescentis, Eschericha_coli and Escherichia-Shigella in BDD group was significantly a

关 键 词：双相障碍 躁狂发作 抑郁发作 认知功能 肠道菌群 

分 类 号：R749.4[医药卫生—神经病学与精神病学]