静脉溶栓治疗急性脑梗死患者的临床疗效及对氧化应激指标水平与神经功能的影响  

Clinical efficacy of intravenous thrombolytic therapy in patients with acute cerebral infarction and its effects on oxidative stress parameter levels and nerve function

作　　者：史帝 周昊[1] 王苗[1] Shi Di;Zhou Hao;Wang Miao(Neurology,Xuzhou First People's Hospital,Xuzhou Jiangsu 221000)

机构地区：[1]江苏省徐州市第一人民医院神经内科

出　　处：《卒中与神经疾病》2019年第4期394-397,共4页Stroke and Nervous Diseases

摘　　要：目的探讨静脉溶栓治疗急性脑梗死患者的临床疗效及对氧化应激指标水平、神经功能的影响。方法用抽签法将于本院2016年2月-2017年10月就诊的81例急性脑梗死患者分为2组,对照组(n=40)采用常规治疗,观察组(n=41)应用静脉溶栓治疗,观察2组的治疗效果及氧化应激指标水平、神经功能变化情况。结果观察组总有效率为95.4%,明显高于对照组62.5%(P<0.05);治疗后观察组各项氧化应激指标水平、NIHSS(美国国立卫生研究院卒中量表)评分、S100B蛋白及BDNF(脑源性神经营养因子)表达水平均明显优于对照组(P<0.05)。结论应用静脉溶栓治疗急性脑梗死患者的临床疗效显著,可有效改善氧化应激指标水平、神经功能。Objective To analyze the clinical effect of intravenous thrombolysis in patients with acute cerebral infarction and its effects on oxidative stress parameter levels and nerve function.Methods 81 patients with acute cerebral infarction from February 2016 to October 2017 were divided into two groups by drawing lots.The control group(n=40)was treated with routine therapy,the observation group(n=41)was treated with intravenous thrombolytic therapy,and the therapeutic effect,nerve function changes and oxidative stress parameter levels were observed and compared between the two groups.Results The total effective rate of the observation group was 95.4%,which was significantly higher than that of the control group(62.5%)(P< 0.05).After treatment,the expression levels of S100B protein and BDNF(brain derived neurotrophic factor) in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Intravenous thrombolytic therapy in patients with acute cerebral infarction was effective in improving oxidative stress parameter levels,nerve function and clinical extension.

关 键 词：脑梗死 静脉溶栓 氧化应激 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]