不同频次无抽搐电休克治疗难治性精神分裂症对照观察  

A comparative study on treatment of treatment-refractory schizophrenia with different frequency modified electroconvulsive therapy

作　　者：胡春水[1] 江文庆[2] 张静[1] 陈翔春[1] 郭本玉[1] 杜亚松[2] HU Chunshui;JIANG Wenqing;ZHANG Jing(Jiading Mental Health Center,Shanghai 201806,China)

机构地区：[1]上海市嘉定区精神卫生中心,上海201806 [2]上海交通大学医学院附属精神卫生中心

出　　处：《国际精神病学杂志》2019年第4期623-625,632,共4页Journal Of International Psychiatry

基　　金：上海市嘉定区卫计委青年课题（编号：2016-QN-03）

摘　　要：目的探讨不同频次无抽搐电休克治疗(MECT)对难治性精神分裂症(TRS)的临床疗效及安全性。方法将80例难治性精神分裂症患者随机分为两组,一组给予1周一次MECT治疗(研究组n=40),另一组给予1周2次MECT治疗(对照组n=40);观察12周,于治疗前及治疗第2周、4周、6周、8周、12周末采用阳性与阴性症状量表(PANSS)评定临床疗效,不良反应量表(TESS)评定不良反应。结果两组PANSS总分均较治疗前有下降(P<0.05);对照组治疗第2、4周末PANSS评分较研究组低,差异有统计学意义(P<0.05),但治疗12周末PANSS评分对比无明显差异(P>0.05);治疗12周末,研究组有效率76.67%,对照组有效率73.33%,两组无显著性差异(P>0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论 MECT对TRS有效,一周两次MECT的疗效和不良反应不优于一周一次。Objective To investigate the effects and side effects of different frequency of modified electroconvulsive therapy(MECT)on treatment-refractive schizophrenia(TRS).Methods 80 cases were randomly divided into 2 groups(experimental group,n=40;control group,n=40).The experimental group received once a week of MECT. Control group was coped with twice a week of MECT. Changes in effective rate,score of positive and negative syndrome scale(positive and negative syndrome scale,PANSS)and treatment emergent symptoms scale(TESS)were then measured after the 2 nd,4 th,6 th,8 th and 12 th weeks of treatment. Results The total scores of PANSS in the two groups were lower than those before treatment(P<0.05);the PANSS scores in the control group were lower than those in the study group at the 2 nd and 4 th weekends of treatment(P<0.05),but there was no significant difference between the two groups at the 12 th weekend of treatment(P>0.05);after the 12 th weekend of treatment,the effective rate of the study group was 76.67%,and that of the control group was 73.33%. There was no significant difference between the two groups(P>0.05). No difference was found in the incidence of side effects between the two groups(P>0.05). Conclusion The efficacy and adverse reactions of twice a week of MECT for patients with refractory schizophrenia were not better than those of once a week of MECT after the 12 th weeks of treatment,suggesting MECT is an effective and safe way for coping with TRS.

关 键 词：难治性精神分裂症 无抽搐电休克治疗 对照研究 

分 类 号：R749.054[医药卫生—神经病学与精神病学]