长期住院男性精神分裂症患者睾酮水平与认知功能的关系  

The relationship of serum testosterone and cognitive function in male long-term inpatients with schizophrenia

作　　者：李金 张晓斌[2] 肖文焕[2] 沙维伟[2] 唐小伟 LI Jin;ZHANG Xiaobin;XIAO Wenhuan(Affiliated Guangji Hospital of Soochow University,Suzhou 215137,China)

机构地区：[1]苏州大学附属广济医院,苏州215137 [2]扬州大学医学院附属五台山医院 [3]南京医科大学附属脑科医院

出　　处：《国际精神病学杂志》2019年第4期641-643,647,共4页Journal Of International Psychiatry

基　　金：苏州市临床医学专家团队引进项目(编号：SZYTD201812);江苏省研究生科研与实践创新计划项目(编号：KYCX18_1497)

摘　　要：目的探讨男性长期住院精神分裂症患者血清总睾酮水平与认知功能的关系。方法使用化学发光免疫分析仪检测80例长期住院男性精神分裂症患者和40例对照的血清总睾酮水平。通过数字划销(DCT)、范畴流畅、空间广度(SS)、连线A、木块图、连续定步调听觉测验检测患者组的认知功能。结果血清总睾酮水平与DCT呈显著正相关(r=0.261,P<0.05),与SS呈显著负相关(r=-0.240,P<0.05)。向后法回归分析在剔除其他影响因素后仍然发现血清总睾酮水平可以显著预测患者在DCT(β=0.240,P=0.028)和SS(β=-0.207,P=0.047)上的表现。结论男性长期住院精神分裂症患者血清总睾酮水平升高时,反映空间记忆和注意方面的认知功能反而下降。Objective To explore the relationship of serum testosterone and cognitive function in male longterm inpatients with schizophrenia. Methods Serum testosterone levels in schizophrenia patients(n=80)and normal controls(n=40)were measured using an chemiluminescent immunoassay analyser. All patients were assessed for performance on cognitive functions using the digit cancellation,semantic fluency test,spatial span(SS),TMT-A,block design and PASAT. Results The serum testosterone levels were largely unrelated to cognitive performance in male long-term inpatients with schizophrenia,but negative correlation with SS score(r=-.230,P<0.05),positive correlation with digit cancellation time(DCT)(r=-.230,P<0.05). Moreover,backward linear regression revealed that testosterone levels significantly predicted performance in DCT(β=0.240,P=0.028)and SS score(β=-0.207,P=0.047). Conclusion We found that there are negative associations between serum testosterone levels with spatial memory and attention in male long-term inpatients with schizophrenia.

关 键 词：精神分裂症 睾酮 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]