细菌脂多糖对选择性激光熔化技术制作的钴铬钼合金离子析出的影响  

Effect of bacterical lipopolysaccharides on ion release from Co-Cr-Mo alloy fabricated by selective laser melting

作　　者：张曼曼 阿地力江·依米提 孙健 程蕙娟[1] 焦婷[1] Zhang Manman;ADILIJIANG-Yimiti;Sun Jian;Cheng Huijuan;Jiao Ting(Shanghai Key Laboratory of Stomatology& Shanghai Research Institute of Stomatology,Shanghai 200011;Department of stomatology,kashgar Prefecture second People's Hospital,Uygur Autonomous Region,840000)

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔修复科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海200011 [2]喀什地区第二人民医院口腔科,喀什844000

出　　处：《口腔材料器械杂志》2019年第3期7-11,共5页Chinese Journal of Dental Materials and Devices

基　　金：上海九院临床研究助力计划资助（编号：JYLJ024）;上海市卫计委卫生行业临床研究专项（编号：201840022）;新疆维吾尔自治区自然科学基金面上项目(编号：2016D01C090)

摘　　要：目的通过ICP-MS测定浸泡液中金属离子含量,研究细菌脂多糖(Lipopolysaccharides,LPS)对选择性激光熔化技术(Selective laser melting,SLM)制作的钴铬钼合金离子析出的影响。方法分别运用SLM技术(SLM组)和传统铸造方法(对照组)制作钴铬钼合金试件支架,每组6个。将每组3个合金试件分别浸泡于单纯人工唾液或加入150μg/mL LPS的人工唾液中,7日后移除合金试件,用ICPMS方法分析溶液中钴(Co)、铬(Cr)、钼(Mo)3种金属离子的析出量。结果与单纯人工唾液相比,对照组浸泡于含LPS的人工唾液中的合金试件的Co离子析出量较高(P<0.05),而SLM组在不同溶液中的离子析出量则无明显差异(P>0.05)。无论在含或不含LPS的人工唾液中,SLM组的Co、Mo离子析出量都远远低于对照组(P<0.05)。结论LPS对SLM制作的钴铬钼合金支架的离子析出量无明显影响。与传统铸造工艺相比,SLM制作的钴铬钼合金支架离子析出量较少。Objective The aim of this studay was to investigate the effect of lipopolysaccharides(LPS)on metal ion release of cobalt-chromium-molybdenum(Co-Cr-Mo)alloy fabricated by selective laser melting technique(SLM)using ICP-MS.Methods Co-Cr-Mo alloys used for framework was fabricated by SLM(SLM group)and traditional cast(control group)technology,and each group included 6 specimens.Every specimen was immersed to the artificial saliva with or without 150μg/mL LPS respectively.The ICP-MS was used to analysis the metal ion release of Co,Cr,Mo for each solution after 7 days.Results Compared to the artificial saliva alone,the value of metal ion release of Co was higher in the control group with 150μg/mL of LPS treatment(P<0.05),while there was no statistically difference between the SLM group with or without LPS treatment(P>0.05).Besides,the value of metal ion release of Co and Mo for the SLM group was much lower than the control group with or without the presence of LPS(P<0.05).Conclusions LPS has no significant impact on the metal ion release of Co-Cr-Mo alloy used for framework fabricated by SLM.Compared to alloy fabricated by the traditional cast technique,the Co-Cr-Mo alloy fabricated by SLM showed less metal ion release.

关 键 词：选择性激光熔化技术 细菌脂多糖 离子析出 钴铬钼合金 

分 类 号：R783.1[医药卫生—口腔医学]